Journal club

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2024-05-01 DOI:10.1136/thorax-2024-221582

Beenish Iqbal

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引用次数: 0

Abstract

Malignant pleural effusion (MPE) is a common problem in advanced malignancies and causes debilitating breathlessness leading to poor quality of life. There are two treatment options available to ‘definitively’ manage MPE which include chest drain with talc pleurodesis and indwelling pleural catheters (IPCs). Although both treatments have been in use for a long time, there has been limited research on the impact of these treatments on patient quality of life. Sivakumar and colleagues (Eur Respir J 2023, DOI: 10.1183/13993003.01215–2022) evaluated the impact of outpatient indwelling pleural catheter with talc slurry vs inpatient chest drain with talc pleurodesis on the quality of life of MPE patients in a multicentre, randomised controlled trial (OPTIMUM). This study was undertaken at 11 hospitals in the UK and one in Australia. 142 patients were randomised 1:1 to the IPC or chest drain. The primary outcome was global health status, measured by a validated EORTC-QLQ C-30 questionnaire at 30 days post-randomisation. An 8-point difference in the score was considered clinically meaningful. There was a statistically significant improvement in the global health status at 30-days in both IPC (mean difference 13.11 [95% CI 5.6 to 21.1]; p=0.001) and chest drain arms (mean difference …

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期刊俱乐部

恶性胸腔积液（MPE）是晚期恶性肿瘤的常见问题，会导致患者呼吸困难，生活质量低下。目前有两种 "明确 "处理 MPE 的治疗方法，包括胸腔引流加滑石粉胸膜穿刺术和留置胸膜导管 (IPC)。虽然这两种治疗方法已经使用了很长时间，但有关这些治疗方法对患者生活质量影响的研究却很有限。Sivakumar 及其同事（Eur Respir J 2023，DOI: 10.1183/13993003.01215-2022）在一项多中心随机对照试验（OPTIMUM）中评估了门诊留置胸膜导管与滑石粉浆对比住院胸腔引流管与滑石粉胸膜穿刺术对 MPE 患者生活质量的影响。这项研究在英国的 11 家医院和澳大利亚的一家医院进行。142名患者以1:1的比例被随机分配到IPC或胸腔引流管。主要结果是随机治疗后 30 天内的总体健康状况，通过有效的 EORTC-QLQ C-30 问卷进行测量。得分相差 8 分即为有临床意义。30天后，IPC（平均差异为13.11 [95% CI 5.6至21.1]；P=0.001）和胸腔引流管臂（平均差异为...

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.