Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study

IF 4.9 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Pub Date : 2024-04-12 DOI:10.1002/trc2.12460

Caterina Rosano, Thomas K. Karikari, Ryan Cvejkus, Bruna Bellaver, Pamela C. L. Ferreira, Joseph Zmuda, Victor Wheeler, Tharick A. Pascoal, Iva Miljkovic

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Abstract

INTRODUCTION

Alzheimer's disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers.

METHODS

In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau-181 (p-tau181), amyloid-beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women.

RESULTS

Women were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age-adjusted p < 0.04). Compared to men, women had worse levels of AD biomarkers, with higher p-tau181 and lower Aβ42/40, independent of covariates (p < 0.001). In sex-stratified analyses, higher p-tau181 was associated with older age in women and with hypertension in men. GFAP and NfL did not differ by sex.

DISCUSSION

Women had worse AD biomarkers than men, unexplained by age, cardiometabolic diseases, or lifestyle. Studying risk factors for AD in PAA is warranted, especially for women earlier in life.

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加勒比海非洲裔人群阿尔茨海默病血液生物标志物的性别差异：多巴哥健康研究

引言在加勒比海地区，阿尔茨海默病（AD）的发病率越来越高，尤其是非洲裔人群（PAA）和女性。然而，这些研究大多采用的是没有阿兹海默症生物标志物的调查。方法在多巴哥健康研究（n = 309；109 位女性，平均年龄为 70.3 ± 6.6）中，我们评估了血清中磷酸化 tau-181 (p-tau181)、淀粉样β (Aβ)42/40 比率、神经胶质纤维酸性蛋白 (GFAP) 和神经丝轻链 (NfL) 水平的性别差异和风险因素。男性血样采集时间为 2010 年至 2013 年，女性血样采集时间为 2019 年至 2023 年。结果女性肥胖、高血压和久坐的比例高于男性，但吸烟和酗酒的比例低于男性（年龄调整后 p <0.04）。与男性相比，女性的注意力缺失症生物标志物水平较低，p-tau181较高，Aβ42/40较低，这与协变量无关（p < 0.001）。在性别分层分析中，女性p-tau181越高与年龄越大有关，男性则与高血压有关。GFAP和NfL没有性别差异。讨论女性的注意力缺失症生物标志物比男性差，年龄、心脏代谢疾病或生活方式都无法解释其原因。有必要对 PAA 中的 AD 风险因素进行研究，尤其是早期女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Medicine-Psychiatry and Mental Health

CiteScore

10.10

自引率

2.10%

发文量

134

审稿时长

10 weeks

期刊介绍： Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.