SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR

IF 2.624

Journal of Magnetic Resonance Open Pub Date : 2024-04-03 DOI:10.1016/j.jmro.2024.100149

Adam Ortmeier , Keilian MacCulloch , Danila A. Barskiy , Nicolas Kempf , John Z Myers , Rainer Körber , Andrey N Pravdivtsev , Kai Buckenmaier , Thomas Theis

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Abstract

Hyperpolarized [1–¹³C]pyruvate is the leading metabolite used in the emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) is a straight forward hyperpolarization method that has recently been shown to hyperpolarize [1–¹³C]pyruvate at low (microtesla and below) magnetic fields. Here, we show that commercial optical magnetometers with Rb-vapor media can be used to readily monitor the build-up and decay of the hyperpolarized MR signal. In addition, we measure ZULF-NMR spectra in various conditions, ranging from a J-coupling-dominated regime transitioning into a Zeeman-dominated regime when going from a sub-nT field to a µT field. The experimentally acquired spectra are matched well by numerical simulations.

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通过零场至超低场 NMR 原位监测 [1-13C] 丙酮酸的 SABRE 超极化动态

超极化[1-13C]丙酮酸是超极化增强磁共振成像这一新兴领域的主要代谢物。通过可逆交换进行信号放大（SABRE）是一种直接的超极化方法，最近已被证明可在低磁场（微特斯拉及以下）下对[1-13C]丙酮酸进行超极化。在这里，我们展示了使用铷原子介质的商用光学磁强计可以随时监测超极化磁共振信号的积累和衰减。此外，我们还测量了各种条件下的 ZULF-NMR 光谱，包括从亚 nT 磁场到 µT 磁场时从 J 耦合主导机制过渡到泽曼主导机制。实验获得的光谱与数值模拟结果非常吻合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Magnetic Resonance Open

CiteScore

1.90

自引率

0.00%

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