Novel monoclonal antibodies: A really specific therapy for light chain amyloidosis

IF 3.3 4区 医学 Q2 HEMATOLOGY
Maria Livia Del Giudice, Sara Galimberti, Gabriele Buda
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引用次数: 0

Abstract

Light chain amyloidosis is a rare disease caused by clonal plasma cells in the bone marrow generating an excessive amount of immunoglobulin light chains. These chains misfold and produce insoluble fibrils that deposit in various organs, including the heart, kidneys, liver, nervous system, and digestive tract. Life expectancy and symptoms during the course of the disease vary depending on which and how many organs are affected. Targeted plasma cell therapy has significantly advanced the clinical management of amyloidosis, with ongoing progress. However, current clinical studies are investigating innovative targets, drug combinations and treatment strategies to improve therapeutic outcomes by minimizing adverse effects and refining patient prognosis in these challenging hematological conditions. In this paper, we review the state of the art regarding the use of anti-amyloid antibodies, as a revolutionary and innovative approach in the current scenario of amyloid treatment.

新型单克隆抗体:轻链淀粉样变性病的真正特异性疗法
轻链淀粉样变性是一种罕见疾病,由骨髓中的克隆浆细胞产生过量的免疫球蛋白轻链引起。这些轻链发生错误折叠并产生不溶性纤维,沉积在各种器官中,包括心脏、肾脏、肝脏、神经系统和消化道。预期寿命和病程中的症状因受影响器官和受影响器官的数量而异。靶向浆细胞疗法大大推进了淀粉样变性病的临床治疗,并不断取得进展。然而,目前的临床研究正在研究创新的靶点、药物组合和治疗策略,以通过最大限度地减少不良反应和改善这些具有挑战性的血液病患者的预后来改善治疗效果。在本文中,我们回顾了抗淀粉样蛋白抗体的使用现状,它是当前淀粉样蛋白治疗中一种革命性的创新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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