Dynamic Level of Fibronectin in Calcium Hydroxide and Mineral Trioxide Aggregate Used as Pulp-Capping Materials

Abstract

Objectives The aim of this study was to evaluate the dynamics of fibronectin levels in teeth treated with pulp capping using calcium hydroxide (Ca(OH)2) and mineral trioxide aggregate (MTA). Materials and Methods Test mice were divided into two treatment groups for pulp capping, with group 1 receiving Ca(OH)2 and group 2 receiving MTA. The maxillary first molars of each group's six rats were pulp capped. After pulp capping, blood samples were collected at 1 hour, 24 hours, and 48 hours. A subsequent analysis of the ELISA—enzyme-linked immunosorbent assay—data was performed on additional samples. Hasanuddin University's Faculty of Medicine's Research Ethics Committee allowed the use of experimental animals. Statistical analysis The data normality test uses the Kolmogorov-Smirnov test (sample > 50) or the Shapiro-Wilk test (sample 50) to identify the analytical application of the distribution of the standard data. Wilk test outcomes had a value of p > 0.05; for both the fibronectin and Shapiro leptin levels, the data are considered to be normally distributed. Results Following the application of Ca(OH)2 and MTA to the treated tooth pulp capping, changes in the levels of leptin and fibronectin were observed after 1 hour, 24 hours, and 48 hours. These changes generally tended to decrease leptin levels and increase fibronectin levels. Conclusion As a pulp-capping material, the results showed that MTA materials have higher levels of dynamics of fibronectin than Ca(OH)2. This indicates MTA is a better material for pulp-capping treatment.