The Protective Effect of L-Arginine against Aspartame-Induced Toxicity on Adrenal Cortex of Adult Male Albino Rats: Histological, Immunohistochemical, and Biochemical Study

Abstract

: Background: Aspartame is widely consumed worldwide. Its metabolites can be toxic to various body organs. L-Arginineis widely available in daily food products and it has an antioxidant property. Aim: This study was done to evaluate the protective effect of L-arginine on aspartame treated adrenal gland in a rat model using histological, immunohistochemical, biochemical, and morphometric studies. Material and Methods: Fifty adult male albino rats five-sixmonthold, weighing180-200 grams were used. They were divided into five groups. Group I(Control). Group II(L-arginine):