Modeling of kinetics of drug desorption from tablet based on polymer matrix

Abstract

Using the literature data, a model has been developed to predict the kinetics of desorption of a drug from a tablet based on hydroxypropyl methylcellulose at different water mixing rates. Upon contact of the tablet with gastric juice, the polymer swelled with the formation of a gel-like shell, which prevents the transfer of gastric juice into the tablet and determines the release rate of the drug into the human body. An equation was used that describes the kinetic dependences of the desorption of a drug in the coordinate system of a conditional time equal to the square root of the observation time. The dependence of the coefficients of the equation on the mixing rate was established, which made it possible to obtain a model for predicting the kinetics of drug desorption from the time of contact with water and the water mixing rate.