INFLUENCE OF INFUSION SOLUTIONS ON CIRCULATING BLOOD VOLUME WITH DIFFERENT ROUTES OF ADMINISTRATION INTO ANIMALS

Fiziolohichnyĭ zhurnal Pub Date : 2024-01-01 DOI:10.15407/fz70.01.060

K.Yu. Krenyov, L. I. Stepanova, N.S. Nikitina, A.I. Sukhodolya

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Abstract

The choice of solution for the initial infusion therapy to restore the volume of circulating blood (CBV) has been a subject of debate for many years. The purpose of our study was to compare the effect of different routes of administration of infusion solutions on CBV. The study was conducted on 250 rats weighing 200-260 g and aged 3-4 months. Animals were born from different females. The dynamics of the neutral red concentration in the gastric perfusate were measured using a 0.9% sodium chloride solution and a 10% albumin solution, which were administered in three different ways. It was established that the intravenous administration of a 0.9% sodium chloride solution at the 60th minute of the experiment reduced the concentration of an aqueous solution of neutral red in the gastric perfusate by 35%, and a 10% albumin solution by 22% compared to the control. This indicates an increase in CBV. When a 0.9% solution of sodium chloride was administered intraosseously, the concentration of an aqueous solution of neutral red significantly decreased by 33% at the 45th minute and by 44% at the 60th minute. On the other hand, under the influence of 10% albumin solution, CBV decreased by 22% at the 45th minute and by 41% at the 60th minute, but not significantly compared to the control. Therefore, the use of these solutions causes an increase in CBV in experimental animals both when administered intravenously and intraosseously, that is, it has similar hemodynamic effects. The retroperitoneal route of administration did not affect CBV changes.

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不同给药途径的输液对动物循环血容量的影响

多年来，为恢复循环血容量（CBV）而选择何种溶液进行初始输注治疗一直是一个争论不休的话题。我们的研究旨在比较不同输液途径对 CBV 的影响。研究对象是 250 只体重 200-260 克、年龄 3-4 个月的大鼠。这些大鼠由不同的雌性大鼠所生。使用 0.9% 氯化钠溶液和 10% 白蛋白溶液，以三种不同的给药方式测量了胃灌注液中中性红浓度的动态变化。实验结果表明，与对照组相比，在实验第 60 分钟静脉注射 0.9% 氯化钠溶液可使胃灌流液中的中性红水溶液浓度降低 35%，10% 白蛋白溶液降低 22%。这表明 CBV 增加了。当鞘内注射 0.9% 的氯化钠溶液时，中性红水溶液的浓度在第 45 分钟时显著下降 33%，在第 60 分钟时下降 44%。另一方面，在 10%白蛋白溶液的影响下，CBV 在第 45 分钟时下降了 22%，在第 60 分钟时下降了 41%，但与对照组相比并不明显。因此，使用这些溶液会导致实验动物的 CBV 增加，无论是静脉注射还是鞘内注射，即具有类似的血液动力学效应。腹膜后给药途径不影响 CBV 的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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