ANTIBACTERIAL ACTIVITY OF DR. RIDZ ANTI-ACNE NANOSERUM® AGAINST SKIN BACTERIA THAT CAUSE ACNE VULGARIS

Jurnal Teknologi Pub Date : 2024-01-15 DOI:10.11113/jurnalteknologi.v86.20885

P.M. Ridzuan, Z. M. Noraziah, Sukri A., Fadzil N. S.

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Abstract

Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus are commonly associated with the pathogenesis of acne vulgaris. Skincare products that contain natural ingredients have become a trend to treat acne. Dr.Ridz Anti-Acne Nanoserum® product was formulated with the extract of Cassia alata leaf and Piper betle. The aim of this study was to determine the antibacterial activity of this formulated product against against C. acnes, S. epidermidis, and S. aureus. The minimum inhibitory concentration (MIC) value and the minimum bactericidal concentration (MBC) were determined using a broth microdilution and a streak plate method, respectively. The rate of killing by this product was tested using time-kill assay (TKA) at 0.5x MIC, 1x MIC, and 2x MIC with incubation periods of 2, 4, 6, 8 10, 12, and 24 hours. The MIC values showed that this product inhibited S. epidermidis and S. aureus better than C. acnes. From the calculation of the MBC/MIC ratio, this product showed bactericidal effects against all tested bacteria. The time-kill studies showed that the killing effect of this product was concentration-dependent, and the highest antibacterial activity was observed at the concentration of 2x MIC against all tested bacteria. In conclusion, Dr.Ridz Anti-Acne Nanoserum® exhibits the best antibacterial activities against S. epidermidis and showed a bactericidal effect towards all tested bacteria. .

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DR.ridz anti-acne nanoserum® 对引起寻常痤疮的皮肤细菌的抗菌活性

痤疮杆菌、表皮葡萄球菌和金黄色葡萄球菌通常与寻常痤疮的发病机制有关。含有天然成分的护肤品已成为治疗痤疮的趋势。Dr.Ridz Anti-Acne Nanoserum® 产品采用决明子叶和胡椒槟榔提取物配制而成。本研究旨在确定该配方产品对痤疮丙酸杆菌、表皮葡萄球菌和金黄色葡萄球菌的抗菌活性。采用肉汤微稀释法和条纹平板法分别测定了最低抑菌浓度（MIC）值和最低杀菌浓度（MBC）。在 0.5 倍 MIC、1 倍 MIC 和 2 倍 MIC 条件下，使用时间杀灭试验（TKA）测试了本品的杀灭率，培养时间分别为 2、4、6、8、10、12 和 24 小时。MIC 值显示，该产品对表皮葡萄球菌和金黄色葡萄球菌的抑制效果优于痤疮丙酸杆菌。从 MBC/MIC 比值的计算结果来看，该产品对所有受测细菌都有杀菌作用。时间杀灭研究表明，该产品的杀灭效果与浓度有关，在 MIC 浓度为 2 倍时，对所有受测细菌的抗菌活性最高。总之，Dr.Ridz Anti-Acne Nanoserum® 对表皮葡萄球菌具有最佳的抗菌活性，对所有测试细菌都有杀菌作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jurnal Teknologi

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审稿时长

20 weeks