In Silico Studies on the Antidiabetic activity of Avicularin

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-01-19 DOI:10.52711/0974-360x.2024.00004

Neeli Parvathi, Rajitha Rajendran, S. Iyyam Pillai, Sorimuthu Pillai Subramanian

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Abstract

Type 2 diabetes mellitus (T2DM) is a worldwide public health crisis. The existing treatments have limitations such as undesirable side effects such as hypoglycemia, unusual weight gain and the development of resistance after prolonged use, which necessitates the development of new therapies for paramount glycemic control, especially those of plant origin. Avicularin, a plant flavonoid and a quercetin glycoside, was originally purified from Psidium guajava. It has been reported to elicit a wide range of pharmacological and beneficial properties especially striking antidiabetic activity. In-silico models have been recognized as being of fundamental importance in the area of research and development of drugs due to their applications both in the evaluation of bioactive substances and in relation to their physicochemical and pharmacokinetic properties, giving rise to a new model of drug design with greater value and efficiency. The aim of the present study was to analyze the molecular interactions between Avicularin andprominent target proteins involved in the commencement and development of diabetes and its secondary complications using an in silico approach.

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关于阿维菌素抗糖尿病活性的硅学研究

2 型糖尿病（T2DM）是一个全球性的公共卫生危机。现有的治疗方法有其局限性，如低血糖、体重异常增加等不良副作用，以及长期使用后产生的抗药性，因此有必要开发新的疗法，尤其是源自植物的疗法，以达到最佳的血糖控制效果。Avicularin是一种植物类黄酮和槲皮素苷，最初是从番石榴中提纯出来的。据报道，它具有广泛的药理作用和益处，尤其是显著的抗糖尿病活性。由于其在生物活性物质评估及其理化和药代动力学特性方面的应用，在药物研究和开发领域中的重要意义已得到公认，从而产生了一种具有更高价值和效率的新药物设计模式。本研究的目的是采用硅学方法分析阿维菌素与涉及糖尿病及其继发性并发症开始和发展的主要靶蛋白之间的分子相互作用。

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.