Probiotics as an Adjunct Approach to the Prevention and Treatment of Colon Cancer: A Review

Current Nutrition & Food Science Pub Date : 2024-01-19 DOI:10.2174/0115734013270901231124063616

Akash Kumar, Nandani Goyal, Jhilam Pramanik, Yashna Bawa, Sudarshan Singh, Bhupendra G. Prajapati

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Abstract

One out of every six people in the world is suffering from cancer disease. The major causes of cancer are high consumption of tobacco, high body mass index, and alcoholic beverages with low intake of a healthy diet and limited physical activity. Colon cancer is one of the leading causes of cancer-related morbidity worldwide. In the past few years, probiotics have drawn a lot of interest as potential preventive and therapeutic anticancer agents. This literature review addressed both human and animal research that has explored the association between probiotics and colon cancer. Probiotic administration has remarkable potential for the prevention and treatment of colon cancer through various mechanisms such as inhibiting the growth of cancer cells via apoptosis, improving immune activity, restoring gut microbiota, improving intestinal barrier properties, synthesizing anticarcinogenic compounds, and degrading carcinogenic compounds. Therefore, probiotics emerge as an adjunct therapy, holding the potential to significantly reduce the risk of colorectal cancer.

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益生菌作为预防和治疗结肠癌的辅助方法：综述

全世界每六人中就有一人患有癌症。癌症的主要诱因是烟草消费量高、体重指数高、酒精饮料多、健康饮食摄入量低和体育锻炼少。结肠癌是全球癌症相关发病率的主要原因之一。在过去几年中，益生菌作为潜在的预防和治疗抗癌药物引起了广泛关注。本文献综述探讨了益生菌与结肠癌之间的人类和动物研究。益生菌可通过多种机制预防和治疗结肠癌，如通过细胞凋亡抑制癌细胞生长、改善免疫活性、恢复肠道微生物群、改善肠道屏障特性、合成抗癌化合物和降解致癌化合物。因此，益生菌成为一种辅助疗法，有可能显著降低结直肠癌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current Nutrition & Food Science

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