Neuro-pharmacological Assessment of Coleus forskohlii for Anti-compulsive Activity in Swiss Albino Mice

Abstract

The aim of the study is to assess Neuro-pharmacological activity of Coleus Forskohlii for anti-compulsive activity in Swiss albino mice Obsessive-Compulsive Disorder (OCD) is a common psychiatric illness characterized by obsessions or compulsions that significantly disrupt or impair daily functioning. Coleus forskohlii, a significant medicinal crop, has forskolin in its roots. It is utilized extensively as food and medicine all over the world. Coleus forskohlii has reputed medicinal uses, which includes antidepressant, anti-aggregant, cAMP-genic, anticancer etc. This study used mice models of marble burying and nestlet shredding to assess the potential efficacy of Coleus forskohlii against obsessive-compulsive disorder. 8-OH-DPAT induced-compulsive checking can demonstrate OCD-like repetitive and obsessive behaviour as well as neurotransmitter imbalance (serotonin). Each group had five mice, and the therapy was administered to the animals for a total of 15 days. On days 1, 7, and 14, the marble burying test was assessed for 30 minutes, and on days 2, 8 and 15, the nestlet shredding test was assessed for 30 minutes. The T-maze paradigm was used to assess anti-OCD activity. The brain histology and morphometry were also performed. When compared to the control group, treatments with Coleus forskohlii (50 and 100 mg/kg, p.o.) significantly enhanced performance on both behaviour tests. The SAB score is dramatically increased following administration of 8-OH-DPAT (2 mg/kg, i.p.) group. Coleus forskohlii (50 and 100 mg/kg, p.o.) and fluoxetine (15 mg/kg, p.o.) groups showed significantly lowered results. Animals treated with 8-OH-DPAT showed a considerable reduction serotonin level. Following Coleus forskholii administration, the histology of the brain tissues showed normal morphological structure with no toxicity or abnormalities. The combination of all these finding points to Coleus forskohlii delivered a possible therapeutic option for the treatment of OCD. The identification and anti-compulsive properties of the components from Coleus forskohlii should be the main aim of future study.