Endocrine Disrupting Effects of Flame Retardants on Thyroid System

Q3 Pharmacology, Toxicology and Pharmaceutics
İ. İyİgÜndoĞdu, I. Cok
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引用次数: 0

Abstract

Accumulating scientific evidence shows that thyroid hormone synthesis and signaling are now recognized as one of the important targets of environmental chemicals, especially chemicals called endocrine disruptors. Endocrine disrupting chemicals (EDCs) are man-made chemicals and consist of different types of molecules, for instance some pesticides, plasticizers, flame retardants (FRs), surfactants, many of which can interfere with thyroid hormone synthesis or their actions. FRs, important members of endocrine disruptors, share similarities in their chemical structures when compared with thyroid hormones, and there is accumulating scientific findings pointing out that they may take part in the dysfunction of thyroid hormone homeostasis. The primary aim of using FRs is to minimize the risk of fire and prevention of its spreading. The potential effects of exposure to FRs on the thyroid and thyroid hormones have gained importance since they may easily migrate into the surrounding environment and are especially found in house dust. Within the framework of the results of some experimental animal and in vitro studies, as well as limited human studies researching the consequences of FRs on the thyroid system, this paper aims to make a general assessment of whether these chemicals have a role in some thyroid diseases. Although the information that FRs with endocrine disrupting properties may have an effect on thyroid hormone levels and cause disruption in the thyroid system is still in its infancy, there is emerging evidence that some members of FRs may have thyroid disrupting properties.
阻燃剂对甲状腺系统的内分泌干扰作用
越来越多的科学证据表明,甲状腺激素的合成和信号传导目前已被公认为是环境化学物质,尤其是被称为内分泌干扰物的化学物质的重要靶标之一。内分泌干扰物(EDCs)是人造化学物质,由不同类型的分子组成,例如一些杀虫剂、增塑剂、阻燃剂(FRs)和表面活性剂,其中许多都能干扰甲状腺激素的合成或作用。阻燃剂是内分泌干扰物的重要成员,其化学结构与甲状腺激素相似,越来越多的科学发现指出,它们可能参与甲状腺激素平衡失调。使用阻燃剂的主要目的是最大限度地降低火灾风险和防止火灾蔓延。接触阻燃剂对甲状腺和甲状腺激素的潜在影响已变得越来越重要,因为它们很容易迁移到周围环境中,尤其是在室内灰尘中。根据一些动物实验和体外研究的结果,以及对阻燃剂对甲状腺系统的影响进行的有限的人体研究,本文旨在对这些化学品是否会导致某些甲状腺疾病进行总体评估。尽管有关具有内分泌干扰特性的FRs可能会对甲状腺激素水平产生影响并导致甲状腺系统紊乱的信息仍处于萌芽阶段,但已有新的证据表明,FRs的某些成员可能具有甲状腺干扰特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Fabad Journal of Pharmaceutical Sciences
Fabad Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.80
自引率
0.00%
发文量
12
期刊介绍: The FABAD Journal of Pharmaceutical Sciences is published triannually by the Society of Pharmaceutical Sciences of Ankara (FABAD). All expressions of opinion and statements of supposed facts appearing in articles and/or advertisiments carried in this journal are published on the responsibility of the author and/or advertiser, anda re not to be regarded those of the Society of Pharmaceutical Sciences of Ankara. The manuscript submitted to the Journal has the requirement of not being published previously and has not been submitted elsewhere. Manuscripts should be prepared in accordance with the requirements specified as given in detail in the section of “Information for Authors”. The submission of the manuscript to the Journal is not a condition for acceptance; articles are accepted or rejected on merit alone. All rights reserved.
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