MATHEMATICAL ANALYSIS OF COVID-19 INFECTION MODEL WITH DEMOGRAPHIC DYNAMICS

Rose Uwanassara Danjuma, P. Okolo, Muhammad Kabir Dauda
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Abstract

This study developed a deterministic mathematical model of COVID-19 infection by incorporating asymptomatically and symptomatically infectious individuals, the vital dynamics such as birth rate and mortality rate. Face mask use, diagnosis of asymptomatic infectious individuals, and isolation of infected individuals as control strategies are also incorporated. The model is shown to have two unique equilibrium states, namely: the disease-free equilibrium points and the endemic equilibrium point. The result from the stability analysis of the critical points is shown to be local asymptotic stable and also, globally asymptotically stable provided the basic reproduction number is less than one (, and the endemic equilibrium state is local asymptotic stable and also, globally asymptotically stable provided . Furthermore, results of the sensitivity index on   for the different parameters of the model show that the recruitment rate and the effective contact rate are the most sensitive parameters and thus critical in disease management and eradication. Thus, efforts geared at reducing the recruitment of susceptible individuals and infection transmission rate will significantly eliminate the disease burden.
具有人口动态变化的科维-19 感染模型的数学分析
本研究建立了 COVID-19 感染的确定性数学模型,将无症状和有症状的感染者、出生率和死亡率等生命动态因素纳入其中。该模型还纳入了口罩的使用、无症状感染者的诊断和感染者的隔离等控制策略。结果表明,该模型有两个唯一的平衡状态,即:无病平衡点和流行平衡点。临界点的稳定性分析结果表明,只要基本繁殖数小于 1,临界点是局部渐近稳定的,而且是全局渐近稳定的();流行平衡状态是局部渐近稳定的,而且是全局渐近稳定的()。此外,模型不同参数的敏感性指数结果表明,招募率和有效接触率是最敏感的参数,因此对疾病管理和根除至关重要。因此,努力减少易感个体的招募和感染传播率将大大减轻疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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