ORAL LICHEN PLANUS IN DRUG-RESISTANT PULMONARY TUBERCULOSIS PATIENT: A RARE CASE

Rani Handayani, Siska Erya Rahim, Virginia Nuriah Hikmawati, Hesti Setiastuti
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Abstract

Drug-resistant pulmonary tuberculosis (DR-TB) is a hurdle in controlling pulmonary tuberculosis. The mucocutaneous tissues, including the oral mucosa, can be impacted by DR-TB medication, although infrequent. Highlighting Oral Lichen Planus (OLP) as a rare oral finding of drug side effects in DR-TB patients. Two male patients in DR-TB Clinic RSUD Tangerang City were referred to the Oral Medicine Clinic for complaints in the oral cavity. Treatment for DR-TB was given to the patient in months 8 and 11. The microscopic examination and sputum culture were negative when consulted. The patient denied any oral cavity complaints before being diagnosed with DR-TB. The intraoral clinical examination showed erosive lesions with a white keratinized plaque on the lips, buccal mucosa, labial mucosa, and tongue consistent with OLP. Pharmacological management involved using corticosteroids for mouthwash and lip ointment with responsive results. Scheduled oral hygiene was also planned to eliminate focus infection in the oral cavity. OLP is a chronic inflammation of the oral mucosa mediated by immunological mechanisms and triggered by various agents. Drugs are one of the known triggers of OLP lesions. The findings of side effects in the oral mucosa tissue are believed to be a result of the DR-TB regimen of these two patients. Long-term drug use triggers the development of OLP in patients with DR-TB. OLP is an oral mucosa finding of drug side effects that is rarely reported in DR-TB patients.
耐药性肺结核患者的口腔扁平苔藓:罕见病例
耐药性肺结核(DR-TB)是控制肺结核的一个障碍。包括口腔黏膜在内的皮肤黏膜组织可能会受到 DR-TB 药物的影响,尽管这种情况并不常见。口腔扁平苔藓(OLP)是 DR-TB 患者口腔发现的一种罕见的药物副作用。坦格朗市 RSUD DR-TB 诊所的两名男性患者因口腔不适被转诊至口腔内科诊所。患者在第 8 个月和第 11 个月接受了 DR-TB 治疗。就诊时,显微镜检查和痰培养均为阴性。在被诊断为 DR-TB 之前,患者否认有任何口腔不适。口腔内临床检查显示,患者的嘴唇、颊粘膜、唇粘膜和舌头上有糜烂性病变和白色角质化斑块,与 OLP 一致。药物治疗包括使用皮质类固醇漱口水和唇膏,效果良好。还计划定期进行口腔卫生检查,以消除口腔内的病灶感染。口腔黏膜炎症是由免疫机制介导的口腔黏膜慢性炎症,由多种因素诱发。药物是 OLP 病变的已知诱因之一。在口腔黏膜组织中发现的副作用被认为是这两名患者使用 DR-TB 方案的结果。长期用药会诱发 DR-TB 患者出现 OLP。OLP是一种口腔黏膜发现的药物副作用,在DR-TB患者中很少见报道。
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