Effect of Intracameral Moxifloxacin on Endothelial Cell Count and Endophthalmitis Prophylaxis After Cataract Surgery

Abstract

One of the most feared side effects of contemporary cataract surgery is still endophthalmitis. Prophylactic measures include the use of antibiotics: topical, subconjunctival, and intracameral, to avoid endophthalmitis. Moxifloxacin 0.5% has been used most frequently in preventive late-stage regimens. Objective: To ascertain how well moxifloxacin prevented endophthalmitis in patients having cataract surgery. Methods: This was a descriptive case study and was conducted at Eye Departments of Allama Iqbal Medical College, Jinnah Hospital, Lahore and Ameer-ud-Din Medical College, Lahore General Hospital, Lahore. The study was commenced after approval of the synopsis and completed in 6 months. Results: In this study, 23.75%(n=19) were between 40-50 years, 61.25%(n=49) between 51-60 years and 15%(n=12) had >60 years of age, and their average was calculated as 53.99+6.22 years. 58.76%(n=47) were males and 41.25%(n=33) were females in the study. Mean endothelial cell count before cataract surgery was calculated as 2776 +177 while post-operative the average endothelial count was calculated as 2424 +72.8. while the frequency of effect of moxifloxacin, in the prevention of endophthalmitis in patients undergoing cataract surgery was recorded as 22.5%(n=18) while 77.5%(n=62) had no effect of moxifloxacin while preventing endophthalmitis in patients undergoing cataract surgery. Conclusions: We conclude that the effect of moxifloxacin, in preventing endophthalmitis in patients undergoing phacoemulsification surgery is not significantly higher and may be used in our setup for prevention of endophthalmitis, being a risk factor for blindness. Moxifloxacin does not affect the corneal endothelial cells significantly.