The Synthesis, Characterization, and Biological Activities of Some Novel Schiff Bases Derived From 3-Acetyl-4-Hydroxy-2H-Chromen-2-One And 2-Aminooxadiazole Derivatives Have Been Investigated

Abstract

A set of five novel Schiff’s bases (5a-e) incorporating coumarin-1, 3, 4-oxadiazole derivative were synthesized through condensation reaction of 3-acetyl-4-hydroxy-2H-chromen-2-one with 2-aminooxadiazole derivatives as heterocyclic aromatic amines. The novel structures of these compounds were confirmed based on their elemental analysis and spectral data. All these investigated derivatives were tested against bacterial species S. aurous, E. coli, S. typhi, B. substilis using the Agar cup method, and against fungal species A. niger, P. chrysogenum, F. moneliforme and A. flavus using poison plate method. Schiff bases incorporating coumarin and 1,3,4-oxadiazole moieties have shown notable efficacy against both bacterial and fungal strains.