Long-term cognitive dysfunction after COVID ARDS

IF 0.1 Q4 ANESTHESIOLOGY

Acta anaesthesiologica Belgica Pub Date : 2024-02-01 DOI:10.56126/75.1.05

L. Vanginderhuysen, B. Janssen, G. Vingerhoets, X. Willaert, A. Creemers, D. Mesotten, S. Thiessen

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引用次数: 0

Abstract

Background: COVID-19 acute respiratory distress syndrome (C-ARDS) survivors suffer from long-term physical complications. However, at the time of this study limited data are available on possible long-term cognitive impairment. Objectives: We hypothesized that COVID-19 ICU patients perform worse on cognitive tasks 6 months after admission, in comparison to reference values of a healthy population. Design: Two-center cohort study with a six months’ time horizon. Patients: Patients admitted to the ICU for COVID-19 associated respiratory failure between March and June 2020. Setting: Post-ICU follow up. Methods and main outcome measures: The primary measure was the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) score (with lower values indicating worse global cognition). The secondary outcome measure was the Trail Making Test (TMT) Part B (population age-, sex-, and education-adjusted mean score, 50±10, with lower scores indicating worse executive functions). The Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE, on a scale from 1.0 to 5.0, with 5.0 indicating severe cognitive impairment) was taken for not patients not fluent in Dutch. Results: 117 COVID-19 patients were admitted to the ICU, of whom 32 patients (27%) died within 6 months. 67/85 (79%) patients participated in the cohort study. COVID-19 survivors had lower total RBANS cognition scores than the age-adjusted population norms (n=45). Fifteen (33%) patients had a global cognition score 1.5 SD below the population means. RBANS-subscale performance showed that both memory (immediate and delayed recall) and attention were at minus 1 SD below normative means, while language and visuospatial cognition were unaffected. Median TMT B score was 40 (IQR 10-65) (n=45). There were elevated scores of the short form IQCODE (mean 3.4 (SD 0.4). Conclusions: Our results suggests that COVID-19 ARDS negatively affects long-term cognitive function. Trial registration: ClinicalTrials.gov NCT04593069.

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COVID ARDS 后的长期认知功能障碍

背景：COVID-19急性呼吸窘迫综合征（C-ARDS）幸存者患有长期的身体并发症。然而，在进行这项研究时，关于可能出现的长期认知障碍的数据却很有限：我们假设，与健康人群的参考值相比，COVID-19 ICU 患者在入院 6 个月后的认知任务表现较差：设计：双中心队列研究，时间跨度为 6 个月：患者：2020年3月至6月期间因COVID-19相关呼吸衰竭入住重症监护室的患者：方法和主要结果测量：主要测量指标是神经心理状态评估可重复性电池（RBANS）得分（数值越低，表示整体认知能力越差）。次要结果测量指标是路径制作测试（TMT）B部分（根据人群年龄、性别和教育程度调整后的平均得分为50±10分，得分越低表明执行功能越差）。对于荷兰语不流利的患者，则采用《老年人认知功能衰退调查问卷简表》（IQCODE，分值从 1.0 到 5.0，5.0 表示严重认知功能障碍）：117 名 COVID-19 患者入住重症监护病房，其中 32 名患者（27%）在 6 个月内死亡。67/85（79%）名患者参与了队列研究。COVID-19 幸存者的 RBANS 认知总分低于年龄调整后的人群标准（45 人）。15名患者（33%）的总体认知得分低于人群平均值 1.5 SD。RBANS 分量表显示，记忆力（即时回忆和延迟回忆）和注意力均比常模平均值低负 1 SD，而语言和视觉空间认知则不受影响。TMT B 评分中位数为 40（IQR 10-65）（n=45）。IQCODE 短表得分升高（平均值为 3.4 (SD 0.4)）：我们的研究结果表明，COVID-19 ARDS对长期认知功能有负面影响：试验注册：ClinicalTrials.gov NCT04593069。

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来源期刊

Acta anaesthesiologica Belgica ANESTHESIOLOGY-

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期刊介绍： L’Acta Anaesthesiologica Belgica est le journal de la SBAR, publié 4 fois par an. L’Acta a été publié pour la première fois en 1950. Depuis 1973 l’Acta est publié dans la langue Anglaise, ce qui a été résulté à un rayonnement plus internationaux. Depuis lors l’Acta est devenu un journal à ne pas manquer dans le domaine d’Anesthésie Belge, offrant e.a. les textes du congrès annuel, les Research Meetings, … Vous en trouvez aussi les dates des Research Meetings, du congrès annuel et des autres réunions.

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