Association of Hyperuricaemia with Angiographic Severity of Coronary Artery Disease in Patients of Acute Coronary Syndrome

Abstract

Background: Coronary artery disease (CAD) is a major cause of death and a global health issue that has reached pandemic proportions in both industrialized and developing countries. Coronary artery disease is primarily caused by atherosclerosis of the epicardial coronary arteries. Aim of the study: The aim of our study was to investigate the relationship between hyperuricemia and the angiographic severity of coronary artery disease in patients who have recently been diagnosed with acute coronary syndrome. Methods: This cross-sectional analytical study was conducted in the department of Cardiology, National Institute of Cardiovascular Diseases and Hospital, Dhaka, Bangladesh, from December 2011 to November 2012. The study included 103 patients who were newly diagnosed as acute coronary syndrome. The individuals in this study were separated into two groups based on their serum uric acid levels. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 11.5. Results: The study populations are mainly between 40 to 75 years (90.6% & 92% remaining in group- I & group- II respectively). It was found that majority of the study participants were male in both groups. Findings of the study shows that there is no statistically significant difference observed in respect smoking habit (p-0.86), hypertension (p-0.32), DM (p-0.53), dyslipidemia p-6.93) and family history of IHD (p-0.68) between two groups. The data of biochemical parameters reveals that HDL level is comparatively lower in group-II (38.72± 2.19) than group- I (39.64 ± 2.11) and it is statistically significant (p=0.03). This study findings reveals that the value of stenosis in Friesinger score in group-II (9.30± 3.96) is remarkably higher than that of group-I (0.77± 3.43) and it is statistically highly significant (p-0.001). Conclusion: This study reveals that hyperuricaemia may be an independent risk factor and predictor of the severity of coronary artery ......