{"title":"Solubility Enhancement of Antidiabetic Drug Pioglitazone by using Polymer Platform Technology","authors":"Nilima Navnath Khakal, Nagesh Hanmantrao Aloorkar","doi":"10.52711/0974-360x.2024.00134","DOIUrl":null,"url":null,"abstract":"A “drug delivery system” should be able to reduce toxicity and improve therapeutic benefits. The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by a novel polymer platform Drug delivery system. Platform technology contains a polymeric system with a release modulator and can accommodate drugs with common physicochemical /therapeutic properties with minimal changes. Pioglitazone, BCS class II drug results in sub-therapeutic plasma drug levels which can cause failure in therapeutic response. When it comes to make PIO dissolved and soluble, microwave assisted ball milling technique was followed. Chitosan and neusiline US2 were used to prepare solid dispersion forming ternary complexation. Optimization of solid dispersion of ternary complexation, a “32 level full factorial design with Design Expert Software version 12” had been used. Pioglitazone–CH-neusiline systems helped in marked development of solubility of initial medicinal water, drug dissolution and drug stability. According to the “FTIR, DSC, and XRPD studies, PIO-CH-NS complexes could be prepared by microwave-assisted milling technology has formed stable crystalline in a ternary complex system. A novel polymer platform technique increases bioavailability, enhancing the therapeutic effect while reducing the toxicity of drug molecules with improving patient compliance.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"187 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Pharmacy and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/0974-360x.2024.00134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
A “drug delivery system” should be able to reduce toxicity and improve therapeutic benefits. The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by a novel polymer platform Drug delivery system. Platform technology contains a polymeric system with a release modulator and can accommodate drugs with common physicochemical /therapeutic properties with minimal changes. Pioglitazone, BCS class II drug results in sub-therapeutic plasma drug levels which can cause failure in therapeutic response. When it comes to make PIO dissolved and soluble, microwave assisted ball milling technique was followed. Chitosan and neusiline US2 were used to prepare solid dispersion forming ternary complexation. Optimization of solid dispersion of ternary complexation, a “32 level full factorial design with Design Expert Software version 12” had been used. Pioglitazone–CH-neusiline systems helped in marked development of solubility of initial medicinal water, drug dissolution and drug stability. According to the “FTIR, DSC, and XRPD studies, PIO-CH-NS complexes could be prepared by microwave-assisted milling technology has formed stable crystalline in a ternary complex system. A novel polymer platform technique increases bioavailability, enhancing the therapeutic effect while reducing the toxicity of drug molecules with improving patient compliance.
期刊介绍:
Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.