A correlation between anxiety-depressive symptoms and immune-metabolic parameters in patients with mixed anxiety and depressive disorder

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) Pub Date : 2024-02-22 DOI:10.33920/med-01-2402-01

N. Bakuleva, O. Shiryaev, V. Zemskova, O. Choporov, A. Zemskov, N. A. Ermolenko, E. V. Dorokhov

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Abstract

According to literature data, anxiety and depressive disorders are the most common mental diseases worldwide. Currently, a hypothesis of possible immune metabolic regulation of the central nervous system was put forward. The authors evaluated the indicators of humoral, cellular, and metabolic immunity in patients suffering from mixed anxiety and depressive disorder, who were under the supervision of a psychiatrist at the day hospital of the Voronezh Regional Clinical Psychoneurological Dispensary. Indicators of anxiety and depression were assessed by means of psychometric method, clinical interview, and clinical psychopathological examination, and the indicators of immune and metabolic status were examined. It was found that symptoms of anxiety and depression were accompanied by changes in immune and metabolic status. It is supposed that variations in clinical, immunological, and metabolic parameters are coordinated elements of a single pathogenetic mechanism for the formation of anxiet y-depressive spectrum disorders.

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混合型焦虑抑郁症患者的焦虑抑郁症状与免疫代谢参数之间的相关性

根据文献资料，焦虑症和抑郁症是全球最常见的精神疾病。目前，有人提出了中枢神经系统可能存在免疫代谢调节的假说。作者对在沃罗涅日地区临床精神神经病疗养院日间医院接受精神科医生指导的混合焦虑症和抑郁症患者的体液免疫、细胞免疫和代谢免疫指标进行了评估。通过心理测量法、临床访谈和临床心理病理学检查对焦虑和抑郁指标进行了评估，并对免疫和新陈代谢状况指标进行了检查。结果发现，焦虑和抑郁症状伴随着免疫和新陈代谢状况的变化。由此推测，临床、免疫和代谢指标的变化是焦虑抑郁谱系障碍形成的单一致病机制的协调要素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)

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