Formulation and Evaluation of Extended Release Oral Suspension of Metformin Hydrochloride

Abstract

The research scheme of formulation and evaluation of extended-release oral suspension of metformin hydrochloride with the objective to develop a stable, redispersible oral liquid suspension based on extended-release pellets to facilitate swallowing in patients with diabetes. Pellets were prepared by using Bed Coating During Sliding method with the Metformin hydrochloride used as antidiabetic drug and various polymers. Extended release was affected by the ethylcellulose coating of drug formulation used as coating agent, MCC, Lactose, PVP K-30 Prepared metformin hydrochloride pellets putted in to prepared sugar free syrup vehicle using polymers like Xanthan Gum as a suspending agent for uniform drug distribution, Sorbitol solution, Aspartame are artificial sweeteners, Sodium Citrate, Potassium sorbate, Methyl paraben. The formulation was optimized based on Design expert software and Central Composite Design was used for study. Drug and polymers were studied for compatibility and interaction study, carried out by FTIR and DSC and found to be compatible to each other. The Redispersibility, Sedimentation volume, Sedimentation rate, Rheological Study, Viscosity, Specific gravity, Particle Size, dissolution study and %Drug content of formulated batches was evaluated. All the results were within the acceptable pharmacopeial limits and were evaluated statistically by using one way ANOVA test for quadratic model. From the result, MET6 batch was observed optimized formulation because up to 8 hrs 85.25% drug was released. kinetic studies of the drug release for optimized formulation follows zero order kinetics.