Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment?

Ageing & Longevity Pub Date : 2024-02-23 DOI:10.47855/jal9020-2024-5-4

O. Halushko, Yanina A. Saienko, Boris Mankovsky

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Abstract

Hypoglycemia is a common complication of diabetes mellitus (DM), which also complicates the course of COVID-19. The aim: The purpose of this work is to analyze the available scientific information on the causes and risk factors of hypoglycemia during the treatment of patients with COVID-19. Materials and methods. Full-text articles were searched and analysed in the PubMed, Web of Science, Google Scholar, and Scopus databases. The search was conducted using the keywords: "hypoglycemia in COVID-19 patients", "treatment of COVID-19 and hypoglycemia" and "COVID-19 vaccination and hypoglycemia" from the beginning of the pandemic in December 2019 to February 1, 2024. Results. The analysis of literary sources showed that hypoglycemia can occur when using drugs from many pharmacotherapeutic groups for the treatment and vaccination of patients with COVID-19. In addition, patients with DM often have chronic complications that contribute to hypoglycemia occurrence in the case of COVID-19. The lockdown during the COVID-19 pandemic has further complicated the problem of hypoglycemia by restricting access to food, clinics, health services, and medicines. Conclusions: Hypoglycemia can be an incidental clinical finding. But it can also be a natural consequence of treatment if it is carried out without taking into account the possible hypoglycemic effects of drugs and without careful monitoring of the patient's condition. In the case of determining the program of treatment and vaccination against COVID-19 in patients with DM, the known and possible hypoglycemic effects of drugs and vaccines should be taken into account, the level of glycemia should be carefully controlled, and sudden changes in the type and dose of drugs, polypharmacy and the use of dangerous combinations of drugs should be avoided. _________________________________________________________________________________________ Keywords: COVID-19, hypoglycemia, treatment, vaccination

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COVID-19 患者出现低血糖：巧合还是治疗的结果？

低血糖是糖尿病（DM）的常见并发症，也使COVID-19的治疗过程复杂化。目的：本研究旨在分析COVID-19患者治疗期间低血糖的原因和风险因素的现有科学信息。在 PubMed、Web of Science、Google Scholar 和 Scopus 数据库中对全文文章进行了检索和分析。搜索关键词为"COVID-19患者低血糖症"、"COVID-19治疗与低血糖症 "和 "COVID-19疫苗接种与低血糖症"。对文献资料的分析表明，使用许多药物治疗组的药物治疗和接种 COVID-19 患者时可能会发生低血糖。此外，DM 患者通常有慢性并发症，这也是 COVID-19 发生低血糖的原因之一。COVID-19 大流行期间的封锁限制了人们获得食物、诊所、医疗服务和药品的机会，从而使低血糖问题变得更加复杂：结论：低血糖可能是一种偶然的临床发现。结论：低血糖可能是一种偶然的临床发现，但如果在治疗过程中没有考虑到药物可能产生的低血糖效应，也没有仔细监测患者的病情，低血糖也可能是治疗的自然结果。在确定DM患者的COVID-19治疗和疫苗接种方案时，应考虑到药物和疫苗已知和可能的低血糖作用，仔细控制血糖水平，避免突然改变药物种类和剂量、使用多种药物和危险的药物组合。_________________________________________________________________________________________关键字：COVID-19COVID-19；低血糖；治疗；疫苗接种

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Ageing & Longevity

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