Melatonin alleviated splanchnic hyperdynamic circulation and portosystemic collaterals in cirrhotic rats

IF 0.3 Q4 GASTROENTEROLOGY & HEPATOLOGY

Advances in Digestive Medicine Pub Date : 2024-02-25 DOI:10.1002/aid2.13390

C. Pun, Ching-Chih Chang, C. Chuang, Shao‐Jung Hsu, Hui-Chun Huang, Ming-Chih Hou, Fa-Yauh Lee

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Abstract

Chronic liver damages may end up with cirrhosis and portal hypertension, featured by splanchnic hyperdynamic circulation, angiogenesis, and collaterals formation. Melatonin is used to improve sleep quality, which exerts anti‐inflammatory, anti‐angiogenesis, and vascular actions without significant side effects. However, the relevant impacts on aforementioned derangements are unclear. Liver cirrhosis was induced by bile duct ligation in Sprague‐Dawley rats. The rats received melatonin (40 mg/kg/day, i.p.) or vehicle for 28 days. Experiments were performed on the 28th day when cirrhosis developed. In cirrhotic rats, melatonin treatment significantly increased superior mesenteric artery resistance and reduced the blood flow. Melatonin enhanced the portosystemic collateral responsiveness to arginine vasopressin, reduced mesenteric vascular area, shunting degree, and down‐regulated mesenteric MMP‐2 protein expression. Melatonin improved the splanchnic hyperdynamic circulation, portosystemic collateral shunting, and mesenteric angiogenesis in cirrhotic rats. These beneficial effects make melatonin potentially feasible in clinical setting, but further investigation is required.

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褪黑素可缓解肝硬化大鼠的脾脏高动力循环和门静脉袢形成

慢性肝损伤最终可能导致肝硬化和门静脉高压，其特点是脾脏高动力循环、血管生成和络脉形成。褪黑素可用于改善睡眠质量，具有抗炎、抗血管生成和血管作用，且无明显副作用。然而，褪黑素对上述失调的相关影响尚不明确。通过胆管结扎诱发 Sprague-Dawley 大鼠肝硬化。大鼠接受褪黑素（40 毫克/千克/天，静脉注射）或药物治疗 28 天。实验在肝硬化发生的第 28 天进行。在肝硬化大鼠中，褪黑激素治疗显著增加了肠系膜上动脉阻力，减少了血流量。褪黑素增强了门静脉侧支对精氨酸血管加压素的反应性，减少了肠系膜血管面积和分流程度，并下调了肠系膜MMP-2蛋白的表达。褪黑素可改善肝硬化大鼠的脾脏高动力循环、门脉侧支分流和肠系膜血管生成。这些有益作用使褪黑素有可能应用于临床，但仍需进一步研究。

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来源期刊

Advances in Digestive Medicine GASTROENTEROLOGY & HEPATOLOGY-

自引率

33.30%

发文量

期刊介绍： Advances in Digestive Medicine is the official peer-reviewed journal of GEST, DEST and TASL. Missions of AIDM are to enhance the quality of patient care, to promote researches in gastroenterology, endoscopy and hepatology related fields, and to develop platforms for digestive science. Specific areas of interest are included, but not limited to: • Acid-related disease • Small intestinal disease • Digestive cancer • Diagnostic & therapeutic endoscopy • Enteral nutrition • Innovation in endoscopic technology • Functional GI • Hepatitis • GI images • Liver cirrhosis • Gut hormone • NASH • Helicobacter pylori • Cancer screening • IBD • Laparoscopic surgery • Infectious disease of digestive tract • Genetics and metabolic disorder • Microbiota • Regenerative medicine • Pancreaticobiliary disease • Guideline & consensus.