A review on solubility enhancement technique for pharmaceutical drugs

Abstract

Solubility, a critical parameter governing the bioavailability and therapeutic efficacy of pharmaceutical compounds, often poses a significant challenge in drug development. This review article offers a thorough examination of several methods used to improve the solubility of medications that have low solubility, in order to overcome their limits. The discussion encompasses both conventional and emerging strategies, highlighting their mechanisms, advantages, and limitations. The study examines conventional methods such as particle size reduction, solid dispersion, and cosolvency, focusing on their historical importance and extensive use. Advances in nanotechnology, including nanosuspensions, nanocrystals, and lipid-based nanocarriers, are discussed for their potential to revolutionize solubility enhancement through improved drug delivery systems. An essential determinant in achieving optimal medication dosage absorption into the circulatory system is the demonstration of a pharmacological action is directly linked to the solubility of a substance. The primary challenge in formulating the new medicinal chemical is its limited water solubility. Medications with low solubility in water need large doses in order to achieve their highest effective concentration in the bloodstream when taken orally. The biopharmaceutical categorization system (BCS) classifies substances according to their solubility and permeability. Regulatory agencies and health organizations have used this categorization approach to validate bioequivalence for chemicals that are both highly soluble and very permeable by using dissolution as a form of confirmation. Medications that have a poor capacity to dissolve in water have a slow pace of breaking down, which results in a reduction in the amount of the medication that may be absorbed into the bloodstream when taken orally.