Nutritional effects on mucosal integrity and immune function

Lindsey B. Cundra, Manasa Vallabhaneni, Kevin V. Houston, Michael Saadeh, Alejandra Vargas, Steve M. D’Souza, David A. Johnson
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引用次数: 0

Abstract

The intestinal mucosal barrier plays a critical role in maintaining the integrity of the gastrointestinal (GI) tract and protecting the body from harmful toxins and pathogens. Nutrition additionally serves as a vital component in maintaining bodily homeostasis. Macronutrients, micronutrients, and specific dietary habits exert profound effects on the immune system. The complex interactions of the immune system reflect a multifaceted, integrated epithelial and immune cell-mediated regulatory system. While several factors can influence the intestinal mucosal barrier and its pro- and anti-inflammatory processes, such as myeloid cell, regulatory T cell (Treg), or intraepithelial lymphocyte populations, there is growing evidence that macronutrients play an essential role in regulating its function. Herein this is a review of the peer-reviewed literature pertaining to dietary effects on mucosal integrity, including intraepithelial lymphocyte populations and immune function. This review is intended to explore the underlying mechanisms by which macronutrients impact and modulate the mucosal immune system.
营养对粘膜完整性和免疫功能的影响
肠粘膜屏障在维持胃肠道(GI)的完整性以及保护人体免受有害毒素和病原体侵害方面发挥着至关重要的作用。此外,营养也是维持身体平衡的重要组成部分。宏量营养素、微量营养素和特定的饮食习惯对免疫系统有着深远的影响。免疫系统复杂的相互作用反映了一个多层面、综合的上皮细胞和免疫细胞介导的调节系统。虽然有多种因素可影响肠粘膜屏障及其促炎和抗炎过程,如髓细胞、调节性 T 细胞(Treg)或上皮内淋巴细胞群,但越来越多的证据表明,宏量营养素在调节肠粘膜屏障功能方面发挥着至关重要的作用。本文综述了有关饮食对粘膜完整性(包括上皮内淋巴细胞群和免疫功能)影响的同行评审文献。本综述旨在探讨宏量营养素影响和调节粘膜免疫系统的内在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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