The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Frontiers in Urology Pub Date : 2024-02-28 DOI:10.3389/fruro.2023.1281081

Bağdagül Aksu, A. C. Afonso, I. Akil, H. Alpay, Bahriye Atmış, Ozlem Aydog, S. Bakkaloğlu, A. Bayazıt, M. Bayram, I. Bilge, I. Bulut, Ayşe Pınar Göksu Çetinkaya, Elif Comak, B. Demir, N. Dinçel, O. Donmez, Mehmet Akif Durmuş, Hasan Dursun, R. Dusunsel, A. Duzova, P. Ertan, A. Gedikbaşı, Nilufer Goknar, S. Guven, D. Hacıhamdioğlu, A. Jankauskienė, M. Kalyoncu, S. Kavukçu, Bahriye Uzun Kenan, Nuran Kuçuk, Bahar Kural, M. Litwin, Giovanni Montini, W. Morello, L. Obrycki, Beyhan Omer, Ebru Misirli Ozdemir, N. Ozkayın, D. Paripović, C. Pehlivanoğlu, S. Saygılı, F. Schaefer, S. Schaefer, F. Sonmez, Y. Tabel, Nesrin Taş, M. Taşdemir, Ana Teixeira, D. Tekcan, R. Topaloğlu, S. Tulpar, Ozde Nisa Turkkan, Berfin Uysal, M. Uysalol, R. Vitkevič, S. Yavuz, Sibel Yel, Tarık Yıldırım, Z. Yildirim, N. Yıldız, Selcuk Yuksel, E. Yurtseven, A. Yılmaz

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Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

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尿热休克蛋白 70 与肾脏和泌尿道先天性异常的关系：UTILISE 研究

先天性肾脏和泌尿道畸形（CAKUT）是指肾脏和/或泌尿道的结构畸形。热休克蛋白（HSP）在肾脏中表达，以应对热、血流动力学、渗透压、炎症和机械压力等细胞变化。本研究旨在评估CAKUT患者在急性尿路感染（UTI）和非感染期间的uHSP70水平，并评估uHSP70在CAKUT亚型中是否升高。研究使用酶联免疫吸附试验（ELISA）测量了uHSP70的水平。CAKUT-A组的uHSP70水平明显高于CAKUT-B组和健康对照组（P < 0.0001）。此外，CAKUT-B 组的 uHSP70 水平明显高于对照组（p < 0.0001），但 CAKUT 亚型之间没有差异（p > 0.05）。此外，与健康对照组相比，CAKUT 患儿在非感染期的尿 HSP70 水平更高。这表明，CAKUT 患儿面临慢性非感染性损害的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Frontiers in Urology

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