Wound healing effect of nutmeg (Myristica fragrans) cream on second-degree burn in animal model

Narra J Pub Date : 2024-02-29 DOI:10.52225/narra.v4i1.621

Ciecielia Angilia, N. L. Sary, R. Indah, S. Suryawati, Bianda S. Farsa, Haya A. Zeir, Fauzan Fajri, Fauzul Husna

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Abstract

Second-degree burn, the most common among burn degrees, underscores the importance of timely and proper treatment in influencing prognosis. Nutmeg (Myristica fragrans), renowned for its potent antibacterial and antifungal properties, also serves as an effective antiseptic for open wounds. The aim of this study was to identify the phytochemical constituents of nutmeg essential oil and analyze the wound healing effect of nutmeg cream on second-degree burns in an animal model. An experimental study with a completed randomized design was conducted on Rattus norvegicus strain Wistar rats with second-degree burn. This study had four groups and each group consisting of four rats: B (burn-treated base cream), B+N (burn-treated 3% nutmeg cream), B+SSD (burn-treated silver sulfadiazine (BSS)), and B+N+SSD (burn-treated 3% nutmeg cream and SSD in a 1:1 ratio). The phytochemical analysis of nutmeg essential oil was conducted by gas chromatography and mass spectroscopy (GC-MS). The burn diameter and burn wound healing percentage were measured from day 0 to 18. One-way ANOVA followed by post hoc analysis using the least significant difference (LSD) was employed to analysis the effect. The phytochemical analysis of nutmeg essential oil found that myristicin, terpinene-4-ol, terpinene, safrole and terpinolene were the most abundant putative compounds in nutmeg essential oil. On day 0, the average burn wound diameters were 1.4 cm in all groups and increases were observed in all groups in day 3. The wound diameter decreased until day 18 with the smallest burn wound diameter was found in the B+N group (0.86±0.37 cm), followed by B+SSD (0.93±0.29 cm). The B+SSD group exhibited the highest percentage of burn wound healing (56.80±14.05%), which was significantly different from the base cream (p<0.05). The percentage of burn wound healing in rats given 3% nutmeg cream was 41.88±13.81% suggesting that nutmeg cream could promote burn wound healing in rats induced by second-degree burns.

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肉豆蔻（Myristica fragrans）膏对动物模型二度烧伤的伤口愈合效果

二度烧伤是烧伤中最常见的程度，因此及时和适当的治疗对预后的影响非常重要。肉豆蔻（Myristica fragrans）以其强大的抗菌和抗真菌特性而闻名，也是开放性伤口的有效防腐剂。本研究旨在确定肉豆蔻精油的植物化学成分，并分析肉豆蔻膏对动物模型二度烧伤的伤口愈合效果。本研究以二度烧伤的野鼠品系 Wistar 大鼠为对象，采用完全随机设计法进行实验研究。该研究分为四组，每组四只大鼠：B（灼伤处理过的基础药膏）、B+N（灼伤处理过的 3% 肉豆蔻膏）、B+SSD（灼伤处理过的磺胺嘧啶银（BSS））和 B+N+SSD（灼伤处理过的 3% 肉豆蔻膏和 SSD 以 1:1 的比例混合）。肉豆蔻精油的植物化学分析采用气相色谱和质谱法（GC-MS）进行。第 0 至 18 天测量烧伤直径和烧伤创面愈合率。采用单因素方差分析和最小显著性差异（LSD）的事后分析来分析效果。肉豆蔻精油的植物化学分析发现，肉豆蔻苷、萜品烯-4-醇、萜品烯、黄樟素和萜品烯是肉豆蔻精油中含量最高的假定化合物。第 0 天，各组烧伤创口的平均直径均为 1.4 厘米，第 3 天各组的创口直径均有所增加。烧伤创口直径在第 18 天前逐渐减小，B+N 组烧伤创口直径最小（0.86±0.37 厘米），其次是 B+SSD（0.93±0.29 厘米）。B+SSD 组的烧伤创面愈合率最高（56.80±14.05%），与基底霜有显著差异（P<0.05）。给予 3% 肉豆蔻膏的大鼠烧伤创面愈合率为 41.88±13.81%，表明肉豆蔻膏可促进二度烧伤大鼠的烧伤创面愈合。

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Narra J

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