“An Overview On Biological Behavior Of Benzotriazole: Synthesis And Docking Study On Its Versatile Biological Activities”

Abstract

The practice of medicinal chemistry is devoted to the discovery and development of new chemical agents for treating diseases. Triazoles are obtained by a slight modification of azole ring and similar or improved activities as well as fewer adverse effects are reported for triazole derivatives several advantages are the notable attraction for using benzotriazole moiety-dependent methodologies, in my research work I synthesized various derivatives of n-(1h-benzotriazol-6-yl)-benzamide from Benzene 1,2,4-triamine and benzoic acid with high yield and the synthesized derivatives characterized by FT-IR spectrum, H1 NMR spectrum, and mass spectrum data of synthesized derivatives compounds of benzotriazole Scheme analysis proves that resultant compounds n-(1h-benzotriazol-6-yl)-benzamide derivatives. The molecular docking studies validated the outcome results from the anti-inflammatory and antiarthritic agents and signifies the potential of these derivatives as crystal structure of C-terminus of voltage-gated sodium channel in complex (PDB ID:4DCK) and COX 2 Inhibitor (PDB ID:1CX2) inhibitors. So, these compounds can be modified further for the development of new anti-inflammatory and antiarthritic agents. This study strongly suggests that most of molecules synthesized in this study may indeed be promising drug candidates with interesting pharmacological profile and most of these derivatives could be a fruitful for further development of better anti-inflammatory and antiarthritic activity.