Post-Operative Blood Glucose Level in Various Anaesthetic Techniques (General & Spinal) Among Non-Diabetics Patients

Abstract

Introduction: The metabolic and hormonal responses to anaesthetics and surgery have been a subject of extensive evaluation and discussion for the past many decades. In normal man, anabolism and catabolism are finely balanced. Surgery produces a stress response resulting in various biochemical and hormonal changes. Apart from surgical stress, anesthesia related procedures like Tracheal intubation, recovery from anesthesia, and post-operative pain can increase the stress induced hormonal changes. This study aims to find out post-operative blood glucose level in various anaesthetic techniques (general & spinal) among non-diabetics patients. Methods: An institution based, observational, cross-sectional study was conducted among patients who were operated at Dept. of Anesthesiology, Anwer Khan Modern Medical College Hospital, Dhaka, Bangladesh from January to December 2022. A total of 120 non diabetes patients who received either general or spinal anesthesia for their surgery. Data was analyzed using SPSS, version 20.0 for windows. Chi-Square test was used to show association between categorical variables and independent sample t-test was used to show mean difference among normally distributed continuous variables. All statistical tests were 2-tailed and a p-value of <0.05 was considered significant. Results: 65.8% of study population received general anesthesia and 34.2% received spinal anesthesia. In postoperative period, 41.6% of study population had their plasma glucose in pre diabetes range and 20.0% had their plasma glucose in diabetes range. Frequency of postoperative hyperglycemia (IFG + Diabetes) was 61.7%. Mean postoperative plasma glucose was significantly higher among study population who received general anesthesia. Increasing age, female gender, overweight, obesity, hypertension and hypothyroidism was significantly associated with high risk of postoperative hyperglycemia. Conclusion: There is high prevalence of postoperative hyperglycemia. The frequency of