Estimation of Urinary C-terminal Telopeptide of Type II Collagen and its Correlation with Radiological Grading, Pain, and Function in Patients with Primary Osteoarthritis of the Knee

Pub Date : 2024-03-05 DOI:10.1177/09733698241229944
R. Nongmaithem, Ranjankumar Singh Lisham, Yengkhom Jotin, Kannamthodi Erumbanottil Shahin, Jerang Obit
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Abstract

To estimate the level of urinary C-terminal telopeptide of type II collagen (uCTX-II) as a biomarker of cartilage turnover and to determine its correlation with radiological grading, pain, and functions of patients with knee osteoarthritis (OA). A descriptive cross-sectional study was conducted between September 2017 and August 2019 on 102 patients suffering from knee OA. Detailed demographic data were collected. uCTX-II level was measured for each patient. Radiological grading, pain and functional assessments were performed using Kellgren-Lawrence (K-L) grading, visual analogue scale (VAS), and Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC). The mean age of 62.3 (6.4) years and most patients (n = 56, 54.9%) were 61–70 years old. Females constituted 80.4% (n = 82). Among the occupations, housewives were more affected (55.9%, n = 57). Out of 102 patients, 32 (31.4%) had VAS pain 4, 25 (24.5%) had 5 and 45 (44.1%) had 6; 9 (8.8%) had K-L score 1, 51 (50%) had 2, 41 (40.2%) had 3 and 1 (1%) had 4; 35(34.3%) had WOMAC score <30, 59 (57.8%) had 30–40, and 8 (7.8%) had >40; 55 ( 53.9%) had uCTX-II level <50 ng/mmole, 25 (24.5%) had between 50 and 200 ng/mmole and 22 (21.6%) had >200 ng/mmole. There was a positive correlation between uCTX-II and WOMAC ( P = .006) and VAS ( P = .042). The present study findings highlighted that higher levels of uCTX-II were associated with higher levels of pain and greater difficulty with daily activities (measured by WOMAC disability score). This suggests that uCTX-II could be a useful biomarker for monitoring cartilage turnover in patients with knee OA and its relationship with pain and functional abilities.
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原发性膝关节骨性关节炎患者尿液中 II 型胶原蛋白 C 端端端肽的估计值及其与放射学分级、疼痛和功能的相关性
旨在估算作为软骨流失生物标志物的尿液中II型胶原蛋白C端端肽(uCTX-II)的水平,并确定其与膝关节骨性关节炎(OA)患者的放射学分级、疼痛和功能的相关性。2017年9月至2019年8月期间,对102名膝关节OA患者进行了一项描述性横断面研究。对每位患者的uCTX-II水平进行了测量。采用凯尔格伦-劳伦斯(K-L)分级、视觉模拟量表(VAS)和西安大略和麦克马斯特大学骨关节炎指数(WOMAC)进行放射学分级、疼痛和功能评估。平均年龄为 62.3(6.4)岁,大多数患者(56 人,54.9%)的年龄在 61-70 岁之间。女性占 80.4%(82 人)。在职业中,家庭主妇的发病率较高(55.9%,n = 57)。在 102 名患者中,32 人(31.4%)的 VAS 疼痛为 4 分,25 人(24.5%)为 5 分,45 人(44.1%)为 6 分;9 人(8.8%)的 K-L 评分为 1 分,51 人(50%)为 2 分,41 人(40.2%)为 3 分,1 人(1%)为 4 分;35 人(34.3%)的 WOMAC 评分为 40 分;55 人(53.9%)的 uCTX-II 水平为 200 ng/mmole。uCTX-II与WOMAC(P = .006)和VAS(P = .042)呈正相关。本研究结果表明,uCTX-II水平越高,疼痛程度越严重,日常活动越困难(以WOMAC残疾评分衡量)。这表明uCTX-II可能是监测膝关节OA患者软骨流失及其与疼痛和功能能力关系的有用生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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