Comparative retrospective analysis: exploring the quality of life of people with epilepsy in two cohorts

Q4 Neuroscience

Neuroscience Research Notes Pub Date : 2024-03-25 DOI:10.31117/neuroscirn.v7i1.310

H. Yow, Kheng-Seang Lim, Melpreet Kuar Bhatt, Si-Lei Fong, Christine Audrey

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引用次数: 0

Abstract

People with epilepsy (PWE) are reported to have a lower quality of life (QOL). QOL among PWE were primarily observed through cross-sectional studies, and there is little information about the progression of QOL among PWE over the years. This study aimed to investigate the changes in QOL among PWE at a tertiary referral centre. A retrospective observational study was conducted among PWE from the Neurology clinic at the University Malaya Medical Centre. Data were extracted from the Quality of Life in Epilepsy Inventory (QOLIE-31) database for 2016, 2017, and 2020. A total of 88 subjects were included in Cohort 1 (2016 vs. 2017) and Cohort 2 (2017 vs. 2020), respectively. There was a significant improvement in mean scores of QOLIE-31 in Cohort 1 (57.7±12.2 vs. 63.2±14.2; p<0.001), in terms of seizure worry, emotional well-being, cognitive functioning, medication effects and social function (p<0.05, respectively). However, significant deterioration was observed in Cohort 2 (67.1±15.6 vs. 63.1±14.9; p=0.008), in terms of seizure worry and cognitive functioning (p<0.05, respectively). Based on the calculated Jacobson Reliable Change Index (RCI) for the QOLIE-31 score, 28.4% from Cohort 2 experienced deterioration of QOL as compared to those from Cohort 1 (8%) (p<0.001), which was most likely attributed to the COVID-19 pandemic. This study provides insights into the change of QOL among PWE in Malaysia over time, encompassing the COVID-19 pandemic period.

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比较性回顾分析：探讨两个队列中癫痫患者的生活质量

据报道，癫痫患者的生活质量（QOL）较低。人们主要通过横断面研究来观察癫痫患者的生活质量，而有关癫痫患者的生活质量随时间推移发生变化的信息却很少。本研究旨在调查一家三级转诊中心的残疾人生活质量的变化。研究人员对马来亚大学医疗中心神经病学诊所的残疾人进行了一项回顾性观察研究。研究人员从癫痫生活质量调查问卷（QOLIE-31）数据库中提取了2016年、2017年和2020年的数据。共有88名受试者分别被纳入队列1（2016年与2017年）和队列2（2017年与2020年）。队列1的QOLIE-31平均得分有明显改善（57.7±12.2 vs. 63.2±14.2；p<0.001），在癫痫发作担忧、情绪健康、认知功能、用药效果和社会功能方面（分别p<0.05）。然而，在组群 2 中，癫痫发作担忧和认知功能方面（分别为 67.1±15.6 vs. 63.1±14.9；p=0.008）出现了明显的恶化（p<0.05）。根据计算得出的 QOLIE-31 评分的雅各布森可靠变化指数 (RCI)，28.4% 的队列 2 患者比队列 1 患者（8%）的 QOL 出现恶化（p<0.001），这很可能是 COVID-19 大流行造成的。这项研究有助于深入了解马来西亚残疾人的 QOL 随 COVID-19 大流行期间的变化情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Research Notes Neuroscience-Neurology

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1.00

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0.00%

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