Assessing adherence and comprehension of cardiovascular medicines with pharmacist intervention post-acute myocardial infarction: a pilot study

IF 1 Q4 PHARMACOLOGY & PHARMACY

Journal of Pharmacy Practice and Research Pub Date : 2024-03-26 DOI:10.1002/jppr.1898

Samia Goni BPharm, GradCertPharmPrac, Adeline Roussety BPharm, PGDipClinPharm, Marianne Jovanovic BPharm (Hons), GradCertPharmPrac, MPharmPrac

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引用次数: 0

Abstract

Background

Due to the addition of multiple new medicines following an acute myocardial infarction (MI), medication non-adherence occurs frequently. Medication education can improve adherence, comprehension, and health-related outcomes. There is currently limited literature about individualised pharmacist-led medication education post-hospital discharge following an MI.

Aim

To assess whether individualised, pharmacist-led education increased patient adherence and comprehension of cardiovascular medicines over a 12-week period following an MI.

Method

All participants completed the Morisky Medication Assessment Scale (MMAS) of self-reported adherence at 1 week and 12 weeks post-hospital discharge. Alongside this, a questionnaire was completed to quantify comprehension of their treatment plan. Participants were randomised to receive individualised pharmacist-led education directed at their medication regimen at 4–6 weeks post-discharge. Data were analysed using paired t-tests and mixed-design analysis of variance (ANOVA). Ethical approval was granted by the Monash Health Human and Research Ethics Committee (Reference no: RES-21-0000234L) and the study conforms to the Australian National Statement on Ethical Conduct in Human Research. Informed consent was obtained from all participants via project information sheets, verbal explanations by recruiting pharmacists with reassurance there would be no difference in standard treatment should patients decline involvement in the project, and written consent forms were completed by all participants.

Results

Of the 29 participants, 15 (51%) received pharmacist-led education. The intervention group's mean MMAS score increased from 6.7 (moderate adherence) at week 1 to 7.6 (moderate adherence) at week 12 post-hospital discharge (p = 0.009). At 12 weeks, the intervention group demonstrated a statistically significant and greater mean MMAS score compared to the control group (7.6 moderate adherence and 6.9 moderate adherence respectively, p = 0.003). The intervention group's mean comprehension level increased from 58% at 1 week to 90% at 12 weeks (p < 0.05). The intervention group demonstrated a greater mean comprehension level at 12 weeks compared to the control group (90% and 48.21% respectively, p < 0.001).

Conclusion

This pilot study demonstrated that individualised, pharmacist-led education may improve self-reported medication adherence and comprehension.

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评估急性心肌梗死后在药剂师干预下服用心血管药物的依从性和理解力：一项试点研究

由于急性心肌梗塞（MI）发生后会增加多种新药，因此经常出现不遵医嘱用药的情况。用药教育可提高用药依从性、药物理解能力和健康相关结果。所有参与者均在出院后 1 周和 12 周内完成了莫里斯基用药评估量表（MMAS）的自我用药依从性评估。同时，他们还填写了一份问卷，以量化对治疗计划的理解程度。参与者在出院后 4-6 周随机接受由药剂师指导的针对其用药方案的个性化教育。数据分析采用配对t检验和混合设计方差分析（ANOVA）。该研究获得了莫纳什卫生部人类与研究伦理委员会的伦理批准（参考编号：RES-21-0000234L），并符合澳大利亚国家人类研究伦理行为声明。通过项目信息表获得了所有参与者的知情同意，招募药剂师进行了口头解释，并保证如果患者拒绝参与该项目，标准治疗不会有任何差别，所有参与者都填写了书面同意书。干预组的 MMAS 平均得分从出院后第 1 周的 6.7（中度依从性）上升到第 12 周的 7.6（中度依从性）（p = 0.009）。与对照组相比，干预组在 12 周时的平均 MMAS 得分显著高于对照组（分别为 7.6 分（中度依从）和 6.9 分（中度依从），p = 0.003）。干预组的平均理解水平从 1 周时的 58% 提高到 12 周时的 90%（p < 0.05）。与对照组相比，干预组在 12 周时的平均理解水平更高（分别为 90% 和 48.21%，p < 0.001）。这项试点研究表明，由药剂师指导的个性化教育可改善自我报告的服药依从性和理解力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy Practice and Research Health Professions-Pharmacy

CiteScore

1.60

自引率

9.50%

发文量

期刊介绍： The purpose of this document is to describe the structure, function and operations of the Journal of Pharmacy Practice and Research, the official journal of the Society of Hospital Pharmacists of Australia (SHPA). It is owned, published by and copyrighted to SHPA. However, the Journal is to some extent unique within SHPA in that it ‘…has complete editorial freedom in terms of content and is not under the direction of the Society or its Council in such matters…’. This statement, originally based on a Role Statement for the Editor-in-Chief 1993, is also based on the definition of ‘editorial independence’ from the World Association of Medical Editors and adopted by the International Committee of Medical Journal Editors.