Change in the functional activity of fibroblasts in patients with coronavirus infection (history of SARS-CoV-2)

Abstract

Introduction. In the genesis of the formation of somatic dysfunction, the leading role is given to adaptive reactions on the part of the body as a whole and connective tissue in particular. The main cells of connective tissue are fibroblasts, which have an important role in the formation of the structural and functional characteristics of connective tissue. There is an opinion that after a coronavirus infection, the adaptive activity of fibroblasts changes in response to external influences.The aim is to study changes in the functional activity of fibroblasts during a simulated compression effect on a culture of fibroblasts obtained from patients who suffered coronavirus infection 3–6 months before the experiment.Materials and methods. Under experimental conditions (in vitro), compression conditions were simulated in relation to a culture of fibroblasts taken from patients who had suffered a coronavirus infection (with a history of SARS-CoV-2) and patients who had no history of coronavirus infection.Results. Under experimental conditions, it was found that fibroblasts from patients who have suffered coronavirus infection have altered functional activity, manifested by a decrease in secreted glycosaminoglycans, elastin and collagen in response to in vitro modeling of the compression factor.Conclusion. The established response of fibroblasts to compression allows us to justify the need for priority elimination of this factor as part of osteopathic correction in patients who have suffered coronavirus infection during treatment and rehabilitation.