Evaluation of Folic Acid Deficiency Anaemia in Predialysis Chronic Kidney Disease Patients: A Hospital-based Study

Eastern Medical College Journal Pub Date : 2024-03-28 DOI:10.3329/emcj.v9i1.71971

Ripon Chandra Mazumder, Supriya Sarker, Saiful Islam, Atm Faruque Ahmed, Ganesh Chandra Halder, Sadiqul Islam Khan

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Abstract

Background: Chronic kidney disease (CKD) is defined as decreasing kidney function for more than 3 months. Anemia is a common complication of CKD due to a decrease in the hormone erythropoietin related to hemoglobin levels. Folic acid helps with the process of nucleoprotein synthesis and erythropoiesis maintenance.Objectives: The aim of the study was to determine the folic acid level in predialytic anaemic chronic kidney disease patients. Methodology: It was a cross-sectional study conducted in the department of Nephrology of Eastern Medical College & Hospital from September 2020 to August 2021 on predialysis CKD anaemic patient of stage-3 to stage-5. A total of 100 subjects were selected by purposive sampling. The age group was 18 to 70 years. Results: Among the 100 subjects mild, Moderate and Severe aneamia were found in 27%, 44% and 29% respectively. Maximum cases showed normocytic normochromic anaeamia (54%) and 7% cases showed macrocytic aneamia. Serum folic acid levels were found to have decreased in 1 (16.7%), 2 (8.33%) and 7 (10.0%) cases and increased in 2 (33.3%), 5 (20.83%) and 21 (30.0%) cases in stage-3, stage-4 and stage-5 respectively. Conclusion: Anemia is a frequent complication of chronic kidney disease. Inadequate production of erythropoietin by the failing kidneys leads to decreased stimulation of the bone marrow to produce red blood cells. Folic acid deficiency may represent an influential factor in renal anemia. Eastern Med Coll J. July 2023; 8 (2): 13-18

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透析前慢性肾病患者叶酸缺乏性贫血的评估：一项医院研究

背景：慢性肾脏病（CKD）是指肾功能下降超过 3 个月。贫血是慢性肾脏病的常见并发症，原因是与血红蛋白水平有关的促红细胞生成素激素减少。叶酸有助于核蛋白合成和红细胞生成的维持：本研究旨在确定贫血前期慢性肾病患者的叶酸水平。研究方法这是一项横断面研究，于 2020 年 9 月至 2021 年 8 月在东方医学院附属医院肾内科进行，对象为透析前慢性肾脏病贫血的 3 至 5 期患者。通过目的性抽样，共选取了 100 名受试者。年龄组为 18 至 70 岁。结果：在 100 名受试者中，轻度、中度和重度无瓣膜症的比例分别为 27%、44% 和 29%。最多的病例表现为正常红细胞正常色素性贫血（54%），7%的病例表现为巨红细胞性贫血。在第三阶段、第四阶段和第五阶段，分别有 1 例（16.7%）、2 例（8.33%）和 7 例（10.0%）患者的血清叶酸水平下降，2 例（33.3%）、5 例（20.83%）和 21 例（30.0%）患者的血清叶酸水平上升。结论贫血是慢性肾脏病的常见并发症。衰竭的肾脏生成的促红细胞生成素不足，导致对骨髓生成红细胞的刺激减少。叶酸缺乏可能是肾性贫血的一个影响因素：13-18

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Eastern Medical College Journal

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