Gastroprotective Effect of Aqueous Extract of Unripe Musa Paradisiaca (Banana) Fruit in Rats with Experimentally Induced Gastric Lesions

Eastern Medical College Journal Pub Date : 2024-03-28 DOI:10.3329/emcj.v9i1.71974

Sharif Mohammad Zabir, Md Jiaul Hasan, Rukhsana Quadir, Sumona Haque, Kazi Sabiha, M. Ahasan, Sabrina Huda Nila, Abu Saleh Md. Salauddin Chowdhury

{"title":"Gastroprotective Effect of Aqueous Extract of Unripe Musa Paradisiaca (Banana) Fruit in Rats with Experimentally Induced Gastric Lesions","authors":"Sharif Mohammad Zabir, Md Jiaul Hasan, Rukhsana Quadir, Sumona Haque, Kazi Sabiha, M. Ahasan, Sabrina Huda Nila, Abu Saleh Md. Salauddin Chowdhury","doi":"10.3329/emcj.v9i1.71974","DOIUrl":null,"url":null,"abstract":"Background: Unripe banana fruit extract is used to relieve stomach distress in some countries. A few studies in India, China, Sudan, Nigeria and South Africa revealed protection of gastric mucosa after exposed to aggressive agent following administration of unripe banana fruit extract in experimental animals. Objective: To determine the protective effect of aqueous extract of unripe Musa paradisiaca (banana) fruit against ethanol induced gastric lesion in rats. Methodology: This was a prospective experimental study carried out in the department of Pharmacology, Dhaka Medical College, Dhaka within the period from January 2015 to June 2015. Aqueous extract of unripe banana fruit was prepared accordingly. Total 24 rats were randomly divided into 4 groups of 6 in each group. Group-A served as a control group and provided with distilled water (5 ml/kg/body weight) orally by gastric tube. Aqueous extract of Musa paradisiaca was administered orally as Group-B: 0.2 mg/kg/body weight/day, Group-C: 0.4 mg/kg/body weight/day and Group-D: 0.8 mg/kg/body weight/day for 7 days. After 7 days, 1 ml absolute ethanol (a known gastric lesion inducing agent) was orally administered to all groups by gastric tube. After 30 minutes of ethanol administration, all rats were sacrificed and dissected. After separating and opening stomachs, observed lesions were examined and measured with some morphological & histological parameters. Obtained data were subjected to analysis by Student’s unpaired t-test. p-value <0.05 was considered as statistically significant. Results: At the end of experiment, Group-A (control) showed a total of 33 gastric lesions. Group-B, Group-C and Group-D showed 22, 20 and 19 stomach lesions respectively. The difference between control group and experiment groups was statistically significant (p<0.01). Conclusion: The unripe banana fruit extract has dose-dependent gastroprotective effect on rats. So, it may be effective in treating peptic ulcer disease.\nEastern Med Coll J. July 2023; 8 (2): 19-23","PeriodicalId":485669,"journal":{"name":"Eastern Medical College Journal","volume":"112 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eastern Medical College Journal","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.3329/emcj.v9i1.71974","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Unripe banana fruit extract is used to relieve stomach distress in some countries. A few studies in India, China, Sudan, Nigeria and South Africa revealed protection of gastric mucosa after exposed to aggressive agent following administration of unripe banana fruit extract in experimental animals. Objective: To determine the protective effect of aqueous extract of unripe Musa paradisiaca (banana) fruit against ethanol induced gastric lesion in rats. Methodology: This was a prospective experimental study carried out in the department of Pharmacology, Dhaka Medical College, Dhaka within the period from January 2015 to June 2015. Aqueous extract of unripe banana fruit was prepared accordingly. Total 24 rats were randomly divided into 4 groups of 6 in each group. Group-A served as a control group and provided with distilled water (5 ml/kg/body weight) orally by gastric tube. Aqueous extract of Musa paradisiaca was administered orally as Group-B: 0.2 mg/kg/body weight/day, Group-C: 0.4 mg/kg/body weight/day and Group-D: 0.8 mg/kg/body weight/day for 7 days. After 7 days, 1 ml absolute ethanol (a known gastric lesion inducing agent) was orally administered to all groups by gastric tube. After 30 minutes of ethanol administration, all rats were sacrificed and dissected. After separating and opening stomachs, observed lesions were examined and measured with some morphological & histological parameters. Obtained data were subjected to analysis by Student’s unpaired t-test. p-value <0.05 was considered as statistically significant. Results: At the end of experiment, Group-A (control) showed a total of 33 gastric lesions. Group-B, Group-C and Group-D showed 22, 20 and 19 stomach lesions respectively. The difference between control group and experiment groups was statistically significant (p<0.01). Conclusion: The unripe banana fruit extract has dose-dependent gastroprotective effect on rats. So, it may be effective in treating peptic ulcer disease. Eastern Med Coll J. July 2023; 8 (2): 19-23

查看原文本刊更多论文

未成熟香蕉麝香果水提取物对实验性胃损伤大鼠的胃保护作用

背景：在一些国家，未成熟香蕉果实提取物被用于缓解胃部不适。印度、中国、苏丹、尼日利亚和南非的一些研究表明，在实验动物体内施用未成熟香蕉果提取物后，可保护暴露于侵蚀性制剂的胃黏膜。研究目的确定未成熟香蕉果实水提取物对乙醇诱导的大鼠胃损伤的保护作用。研究方法：这是一项前瞻性实验研究：这是一项前瞻性实验研究，于 2015 年 1 月至 2015 年 6 月期间在达卡医学院药理学系进行。据此制备了未成熟香蕉果实的水提取物。24 只大鼠被随机分为 4 组，每组 6 只。A 组为对照组，通过胃管口服蒸馏水（5 毫升/千克/体重）。B 组：0.2 毫克/千克/体重/天；C 组：0.4 毫克/千克/体重/天；D 组：0.8 毫克/千克/体重/天，连续 7 天。7 天后，用胃管给各组口服 1 毫升绝对乙醇（已知的胃损伤诱导剂）。给药 30 分钟后，所有大鼠均被处死并解剖。分离和打开胃后，用一些形态学和组织学参数检查和测量观察到的病变。获得的数据采用学生非配对 t 检验进行分析，p 值小于 0.05 视为具有统计学意义。结果实验结束时，A 组（对照组）共有 33 处胃部病变。B组、C组和D组的胃部病变分别为22、20和19个。对照组和实验组之间的差异有统计学意义（P<0.01）。结论未成熟香蕉果实提取物对大鼠具有剂量依赖性胃保护作用。Eastern Med Coll J. July 2023; 8 (2)：19-23

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Eastern Medical College Journal

自引率

0.00%

发文量