Analytical Method: Determination of famotidine drug using chemiluminescence method

Shatha Al-Samarrai
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引用次数: 0

Abstract

This study involved the development of a novel, cost-effective, fast, and highly sensitive analytical technique for quantifying minimal amounts of the drug famotidine through chemiluminescence. The method is centred around the measurement of energy emitted as a result of the interaction between the drug and Luminol in an alkaline solution; this interaction generates an electronically excited intermediate state, releasing a portion of the system’s energy as photons. The method was sensitive for the analysis of famotidine. The linear calibration curve (LR) is obtained in the range 2-12 mg mL-1, with a high correlation coefficient (R2) of 0.9929. The molecular absorption coefficient  (ε) was calculated at 2621×104 L mol-1 cm-1. The method displayed excellent sensitivity with a Sandell’s sensitivity of 1.287×10-5 mg cm-2, the detection limit (LOD) was found to be 0.0314 mg mL-1, and the limit of quantification (LOQ) was 0.0952 mg mL-1. This study found that recovery was obtained at 104 - 96.5 %, and the relative standard deviation (RSD%) was below 1.981%. The results showed that the proposed technique has efficient recovery for measuring famotidine in pharmaceutical preparations.
分析方法:使用化学发光法测定法莫替丁药物
这项研究涉及开发一种新颖、经济、快速和高灵敏度的分析技术,通过化学发光对药物法莫替丁进行最小量的定量分析。该方法的核心是测量药物和鲁米诺在碱性溶液中相互作用所释放的能量;这种相互作用会产生一个电子激发中间态,以光子的形式释放出系统的部分能量。该方法对法莫替丁的分析非常灵敏。在 2-12 mg mL-1 范围内获得了线性校准曲线(LR),相关系数(R2)高达 0.9929。分子吸收系数(ε)为 2621×104 L mol-1 cm-1。该方法灵敏度高,桑德尔灵敏度为 1.287×10-5 mg cm-2,检出限(LOD)为 0.0314 mg mL-1,定量限(LOQ)为 0.0952 mg mL-1。研究发现,回收率为 104 - 96.5%,相对标准偏差(RSD%)低于 1.981%。结果表明,所提出的技术在测定药物制剂中的法莫替丁时具有高效的回收率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.10
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