Chronotherapy for Cancer Treatment: A Review of Timing Strategies

Abstract

Chronotherapy, the delivery of drugs in accordance with the body's circadian cycle, has become a promising strategy to increase the effectiveness and lower the toxicity of cancer treatment. Cell division, DNA repair, and metabolism are three physiological functions regulated by the circadian clock that are known to affect how well anti-cancer treatments work. This study reviews the present status of research on timing techniques in order to offer a thorough overview of chronotherapy in the treatment of cancer. The review starts off by going over the basic ideas of circadian rhythms and how they relate to cancer biology. The justification for adopting chronotherapy to improve treatment results is then discussed, including the possibility of increasing therapeutic efficacy while reducing side effects. A full analysis of preclinical research is then provided, emphasizing the influence of treatment scheduling on drug metabolism, host-tumor interactions, and tumor growth inhibition. The significance of taking circadian rhythms into account while developing cancer treatment plans is emphasized in this study. The complicated interactions between circadian biology, tumor dynamics, and treatment effects are highlighted, underscoring the need for more study. In the end, utilizing the power of chronotherapy has the potential to transform cancer treatment by customizing regimens based on each patient's inherent rhythms.