A Comparative Kinetic Study of Uncatalyzed and Ce(IV) Catalyzed Cetrizine Dihydrochloride Oxidation in Aqueous Acid Medium by Chloramine-T

Abstract

A kinetic study of uncatalyzed and Ce(IV) catalyzed cetrizine dihydrochloride oxidation was carried out in aqueous acid medium using chloramine-T. Both uncatalyzed and catalyzed reactions follows first order kinetics with respect to [CAT] and fractional order kinetics with respect to [substrate]. The reaction follows first order dependence on [CeIV] catalyst. The uncatalyzed reaction shows inverse fractional order for [H+] and [Cl–] whereas catalyzed reaction follows fractional order. The effect of ionic strength is negligible in both cases. The dielectric constant has negative effect on uncatalyzed reaction and positive effect on catalyzed reaction. To compute the thermodynamic parameters the kinetic runs were studied at different temperatures (293-313 K). The stoichiometry of the reaction was studied and the products of oxidation were analyzed. The rate law was also derived by the proposed mechanism.