Metformin acts through appetite-suppressing metabolite: Lac-Phe

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-04-02 DOI:10.1038/s41574-024-00986-w

Shimona Starling

引用次数: 0

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二甲双胍通过抑制食欲的代谢物发挥作用：漆酚

二甲双胍是治疗 2 型糖尿病（T2DM）的一线药物，其作用是降低血糖水平、减少食物摄入量和体重。二甲双胍治疗效果背后的机制尚未完全明了，人们提出了各种作用模式。现在，同时发表在《自然-代谢》（Nature Metabolism）杂志上的两项独立研究指出了一种抑制食欲的代谢物--N-乳酰基苯丙氨酸（Lac-Phe）的作用。二甲双胍治疗可增加体外、小鼠和人体中的Lac-Phe水平。在原代小鼠巨噬细胞、Caco-2细胞（一种人类肠道上皮细胞系）和BV-2细胞（一种小鼠小胶质细胞系）中进行的进一步研究表明，二甲双胍具有抑制复合体I和驱动Lac-Phe生物合成的作用。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.