A Comprehensive Review of Membrane Transporters and MicroRNA Regulation in Alzheimer's Disease.

IF 4.6 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2024-11-01 Epub Date: 2024-04-01 DOI:10.1007/s12035-024-04135-2

Shatakshi Mishra, B Stany, Anushka Das, Deepankumar Kanagavel, Murali Vijayan

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引用次数: 0

Abstract

Alzheimer's disease (AD) is a distressing neurodegenerative condition characterized by the accumulation of amyloid-beta (Aβ) plaques and tau tangles within the brain. The interconnectedness between membrane transporters (SLCs) and microRNAs (miRNAs) in AD pathogenesis has gained increasing attention. This review explores the localization, substrates, and functions of SLC transporters in the brain, emphasizing the roles of transporters for glutamate, glucose, nucleosides, and other essential compounds. The examination delves into the significance of SLCs in AD, their potential for drug development, and the intricate realm of miRNAs, encompassing their transcription, processing, functions, and regulation. MiRNAs have emerged as significant players in AD, including those associated with mitochondria and synapses. Furthermore, this review discusses the intriguing nexus of miRNAs targeting SLC transporters and their potential as therapeutic targets in AD. Finally, the review underscores the interaction between SLC transporters and miRNA regulation within the context of Alzheimer's disease, underscoring the need for further research in this area. This comprehensive review aims to shed light on the complex mechanisms underlying the causation of AD and provides insights into potential therapeutic approaches.

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全面回顾阿尔茨海默病中的膜转运体和 MicroRNA 调控。

阿尔茨海默病（AD）是一种令人痛苦的神经退行性疾病，其特征是大脑内淀粉样β（Aβ）斑块和tau缠结的累积。膜转运体（SLCs）和microRNAs（miRNAs）在AD发病机制中的相互联系日益受到关注。这篇综述探讨了 SLC 转运体在大脑中的定位、底物和功能，强调了谷氨酸、葡萄糖、核苷和其他重要化合物的转运体的作用。该研究深入探讨了 SLC 在注意力缺失症中的重要性、其在药物开发中的潜力，以及 miRNA 的复杂领域，包括其转录、处理、功能和调控。miRNA已成为AD的重要参与者，包括与线粒体和突触相关的miRNA。此外，本综述还讨论了以 SLC 转运体为靶点的 miRNA 及其作为 AD 治疗靶点的潜力这一引人入胜的关联。最后，综述强调了阿尔茨海默病背景下 SLC 转运体与 miRNA 调控之间的相互作用，强调了在这一领域开展进一步研究的必要性。这篇全面的综述旨在揭示导致阿尔茨海默病的复杂机制，并为潜在的治疗方法提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.