Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds.

IF 4.8 4区医学 Q2 IMMUNOLOGY

International immunology Pub Date : 2024-07-13 DOI:10.1093/intimm/dxae019

Kazuya Iwabuchi, Masashi Satoh, Kazuhisa Yoshino, Naoki Ishimori

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引用次数: 0

Abstract

Invariant natural killer T (iNKT) cells, which bear αβ-type T-cell antigen-receptors (TCRs), recognize glycolipid antigens in a cluster of differentiation 1d (CD1d)-restricted manner. Regarding these cells, the unique modes of thymic selection and maturation elucidate innateness, irrespective of them also being members of the adaptive immune system as a T-cell. iNKT cells develop and differentiate into NKT1 [interferon γ (IFN-γ)-producing], NKT2 [interleukin 4 (IL-4)/IL-13-producing], or NKT17 (IL-17-producing) subsets in the thymus. After egress, NKT10 (IL-10-producing), follicular helper NKT (NKTfh; IL-21-producing), and regulatory NKT (NKTreg) subsets emerge following stimulation in the periphery. Moreover, iNKT cells have been shown to possess several physiological or pathological roles. iNKT cells exhibit dual alleviating or aggravating roles in experimentally induced immune and/or inflammatory diseases in mice. These findings indicate that the modulation of iNKT cells can be employed for therapeutic use or prevention of human diseases. In this review, we discuss the potential roles of iNKT cells in the development of immune/inflammatory diseases of the cardiovascular system, with emphasis on atherosclerosis, aortic aneurysms, and cardiac remodeling.

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关于不变自然杀伤 T 细胞在具有免疫和炎症背景的心血管疾病中的潜在作用的最新进展。

不变自然杀伤 T 细胞（iNKT）带有 αβ 型 T 细胞抗原受体，能以分化 1d 簇（CD1d）限制的方式识别糖脂抗原。iNKT细胞在胸腺中发育并分化成NKT1[产生干扰素γ（IFN-γγ）]、NKT2[产生白细胞介素4（IL-4）/IL-13]或NKT17（产生IL-17）亚群。出境后，NKT10（产生 IL-10）、滤泡辅助 NKT（NKTfh；产生 IL-21）和调节性 NKT（NKTreg）亚群在外周受到刺激后出现。iNKT 细胞在小鼠实验性免疫和/或炎症性疾病中表现出双重缓解或加重作用。这些发现表明，调节 iNKT 细胞可用于治疗或预防人类疾病。在这篇综述中，我们将讨论 iNKT 细胞在心血管系统免疫/炎症性疾病发展过程中的潜在作用，重点是动脉粥样硬化、主动脉瘤和心脏重塑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunology 医学-免疫学

CiteScore

9.30

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.