Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia.

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Drugs & Aging Pub Date : 2024-05-01 Epub Date: 2024-04-02 DOI:10.1007/s40266-024-01111-2

Rizwan Qaisar, Imran M Khan, Asima Karim, Tahir Muhammad, Firdos Ahmad

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引用次数: 0

Abstract

Purpose: Statins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscular junction (NMJ) integrity. However, their association with the sarcopenia-related-quality-of-life (SarQoL) is unknown.

Methods: In this cross-sectional, case control study, we recruited male nonusers (n = 75 and age 75.2 ± 5.9 years) and users (n = 77 and age 77.1 ± 6.2 years) of statins to evaluate SarQoL and handgrip strength (HGS). We also measured plasma C-terminal agrin fragment-22 (CAF22) as a marker of NMJ degradation.

Results: Statin users had higher CAF22, and lower HGS, and cumulative SarQoL scores than non-users (all p < 0.05). Plasma CAF22 exhibited negative correlations with SarQoL scores for physical and mental health, locomotion, functionality, activities-of-daily-living, and cumulative SarQoL in statins users and non-users (all p < 0.05). Lastly, the cumulative SarQoL scores exhibited positive associations with HGS and gait speed in the study participants (all p < 0.05).

Conclusions: Collectively, statin usage was associated with NMJ degradation and reduced SarQoL. Statins should be cautiously prescribed in patients with sarcopenia with reduced QoL.

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降脂药物与患有高血脂症的老年人肉质疏松相关的生活质量降低有关。

目的：他汀类药物会对与年龄相关的肌肉质量和力量损失（称为 "肌肉疏松症"）以及神经肌肉接头（NMJ）完整性产生负面影响。然而，它们与肌肉疏松症相关生活质量（SarQoL）的关系尚不清楚：在这项横断面病例对照研究中，我们招募了他汀类药物的男性非使用者（n = 75，年龄为 75.2 ± 5.9 岁）和使用者（n = 77，年龄为 77.1 ± 6.2 岁），以评估肌肉疏松相关生活质量（SarQoL）和手握力（HGS）。我们还测量了血浆中作为 NMJ 降解标志物的 C-terminal agrin fragment-22 (CAF22)：结果：与不使用他汀类药物者相比，使用他汀类药物者的 CAF22 较高、HGS 较低、SarQoL 累积得分较低（均为 p总之，他汀类药物的使用与 NMJ 退化和 SarQoL 降低有关。他汀类药物应慎用于质量生活水平下降的肌肉疏松症患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drugs & Aging 医学-老年医学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Drugs & Aging delivers essential information on the most important aspects of drug therapy to professionals involved in the care of the elderly. The journal addresses in a timely way the major issues relating to drug therapy in older adults including: the management of specific diseases, particularly those associated with aging, age-related physiological changes impacting drug therapy, drug utilization and prescribing in the elderly, polypharmacy and drug interactions.