The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-04-01 Epub Date: 2024-04-02 DOI:10.1007/s12012-024-09848-3
Mahdi Mousavi Mele, Atefeh Tahavorgar, Zahra Salimi, Ali Shaker, Seyed Ali Askarpour, Mohammad Keshavarz Mohammadian, Seyed Reza Mirshafaei, Zahra Saeedirad, Mahdie Torkaman, Zahra Mahmoudi, Shirin Tajadod, Sara Khoshdooz, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh
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引用次数: 0

Abstract

Previous studies reported that iron may have an indispensable role in the risk of hypertension (HTN). However, the result of the studies on the relationship between iron and risk of HTN is inconsistent. This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case-control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94-0.99, P = 0.04). The association remained significant after adjustment for age, gender, smoking, drinking alcohol, calorie intake, and BMI (OR = 0.94, CI 95%: 0.89-0.98, P = 0.01). As a conclusion, iron intake was inversely associated with HTN. Further longitudinal studies on the effect of iron intake on BP are required to confirm this finding.

铁摄入量与高血压的关系,铁摄入量会降低血压吗?
以往的研究表明,铁在高血压(HTN)风险中可能扮演着不可或缺的角色。然而,有关铁与高血压风险之间关系的研究结果并不一致。本研究旨在评估伊朗人群膳食铁摄入量与高血压之间的关系。这项病例对照研究的对象是伊朗 Sabzevar 的 4184 名 35 至 70 岁的人群,其中包括 1239 名高血压患者和 2945 名血压正常者。膳食摄入量通过食物频率问卷(FFQ)进行评估。在评估膳食中铁的摄入量时,使用了营养学家 IV 软件。研究发现,铁摄入量与高血压之间存在反向关系(OR = 0.97,CI 95%:0.94-0.99,P = 0.04)。在对年龄、性别、吸烟、饮酒、卡路里摄入量和体重指数进行调整后,两者之间的关系仍很明显(OR = 0.94,CI 95%:0.89-0.98,P = 0.01)。综上所述,铁的摄入量与高血压呈反向关系。要证实这一发现,还需要进一步开展铁摄入量对血压影响的纵向研究。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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