Optimal Neoantigen Cancer Vaccines Target CD8+ and CD4+ T Cells with Multiple Antigens.

IF 8.1 1区医学 Q1 IMMUNOLOGY

Cancer immunology research Pub Date : 2024-04-02 DOI:10.1158/2326-6066.CIR-24-0165

Craig L Slingluff

引用次数: 0

Abstract

Cancer vaccines targeting mutated neoantigens offer promise for prevention of cancer recurrence and for treatment of established cancers. Questions remain about whether vaccines need to target multiple neoantigens and whether they need to target both CD8+ and CD4+ T cells. In this issue, Garzia and colleagues demonstrate the importance of including multiple antigens to stimulate both CD4+ T cells and CD8+ T cells for treatment of established cancer. See related article by Garzia et al., p. 440 (4).

查看原文本刊更多论文

最佳新抗原癌症疫苗靶向 CD8+ 和 CD4+ T 细胞与多种抗原。

针对突变新抗原的癌症疫苗有望预防癌症复发和治疗已确诊的癌症。疫苗是否需要针对多种新抗原，是否需要同时针对 CD8+ 和 CD4+ T 细胞，这些问题依然存在。在本期杂志中，Garzia 及其同事证明了包含多种抗原以刺激 CD4+ T 细胞和 CD8+ T 细胞对治疗已确诊癌症的重要性。请参阅 Garzia 等人的相关文章，第 440 页（4）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer immunology research ONCOLOGY-IMMUNOLOGY

CiteScore

15.60

自引率

1.00%

发文量

260

期刊介绍： Cancer Immunology Research publishes exceptional original articles showcasing significant breakthroughs across the spectrum of cancer immunology. From fundamental inquiries into host-tumor interactions to developmental therapeutics, early translational studies, and comprehensive analyses of late-stage clinical trials, the journal provides a comprehensive view of the discipline. In addition to original research, the journal features reviews and opinion pieces of broad significance, fostering cross-disciplinary collaboration within the cancer research community. Serving as a premier resource for immunology knowledge in cancer research, the journal drives deeper insights into the host-tumor relationship, potent cancer treatments, and enhanced clinical outcomes. Key areas of interest include endogenous antitumor immunity, tumor-promoting inflammation, cancer antigens, vaccines, antibodies, cellular therapy, cytokines, immune regulation, immune suppression, immunomodulatory effects of cancer treatment, emerging technologies, and insightful clinical investigations with immunological implications.

文献相关原料

公司名称	产品信息	采购帮参考价格