Virucidal efficacy of hypochlorous acid water for aqueous phase and atomization against SARS-CoV-2

Makoto Kubo, Ryotaro Eda, Shotaro Maehana, Hiroshi Fuketa, Norihiro Shinkai, Naohisa Kawamura, Hidero Kitasato, Hideaki Hanaki
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Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, and chlorine-releasing agents, including hypochlorous acid, are used to prevent the spread of SARS-CoV-2 infection. In the present study, we investigated the efficacy of ionless hypochlorous acid water (HOCl) in suspension and by spraying to inactivate SARS-CoV-2. The virucidal efficacy of HOCl solution in tests against SARS-CoV-2 was evaluated as 50% tissue culture infectious dose. Although the presence of organic compounds influenced the virucidal efficacy, HOCl treatment for 20 s was significantly effective to inactivate Wuhan and Delta strains in the suspension test. HOCl atomization for several hours significantly reduced the SARS-CoV-2 attached to plastic plates. These results indicate that HOCl solution with elimination containing NaCl and other ions may have high virucidal efficacy against SARS-CoV-2. This study provides important information about the virucidal efficacy and use of HOCl solution.

水相次氯酸水和雾化次氯酸水对 SARS-CoV-2 的杀毒功效
View largeDownload slideView largeDownload slide Close modal冠状病毒病2019(COVID-19)是由严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)引起的传染性病毒病,于2019年底出现。SARS-CoV-2 可通过飞沫、气溶胶和飞沫传播。酒精、季铵盐和氯释放剂(包括次氯酸)等消毒剂被用来防止 SARS-CoV-2 感染的传播。在本研究中,我们研究了无离子次氯酸水(HOCl)悬浮液和喷雾灭活 SARS-CoV-2 的功效。在针对 SARS-CoV-2 的测试中,HOCl 溶液的杀毒效果以 50%的组织培养感染剂量进行评估。虽然有机化合物的存在会影响杀毒效果,但在悬浮液试验中,20 秒的 HOCl 处理对武汉株和三角洲株的灭活效果显著。雾化数小时的 HOCl 能明显减少附着在塑料板上的 SARS-CoV-2 。这些结果表明,含有 NaCl 和其他离子的 HOCl 溶液可能对 SARS-CoV-2 有很高的杀毒功效。这项研究为 HOCl 溶液的杀毒功效和使用提供了重要信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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