Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy

IF 9.7 1区化学 Q1 CHEMISTRY, PHYSICAL

Journal of Colloid and Interface Science Pub Date : 2024-03-27 DOI:10.1016/j.jcis.2024.03.175

Chuanqi Feng , Lumin Wang , Dashuai Zhang , Longlong Geng , Lianwen Zhou , Ling Wang , Guanfeng Tian , Qi Tang , Jinyan Hu , Bijiang Geng , Lang Yan

{"title":"Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy","authors":"Chuanqi Feng , Lumin Wang , Dashuai Zhang , Longlong Geng , Lianwen Zhou , Ling Wang , Guanfeng Tian , Qi Tang , Jinyan Hu , Bijiang Geng , Lang Yan","doi":"10.1016/j.jcis.2024.03.175","DOIUrl":null,"url":null,"abstract":"<div>The efficacy of electron-hole separation in a single sonosensitizer and the complexities of the tumor microenvironment (TME) present significant challenges to the effectiveness of sonodynamic therapy (SDT). Designing efficient sonosensitizers to enhance electron-hole separation and alleviate TME resistance is crucial yet challenging. Herein, we introduce a novel Z-scheme heterojunctions (HJs) sonosensitizer using Fe-doped carbon dots (CDs) as auxiliary semiconductors to sensitize cubic Cu2O (Fe-CDs@Cu2O) for the first time. Fe-CDs@Cu2O demonstrated enhanced SDT effects due to improved electron-hole separation. Additionally, the introduction of Fe ions in CDs synergistically enhances Fenton-like reactions with Cu ions in Cu2O, resulting in enhanced chemodynamic therapy (CDT) effects. Moreover, Fe-CDs@Cu2O exhibited rapid glutathione (GSH) depletion, effectively mitigating TME resistance. With high rates of 1O2 and <img>OH generated by Fe-CDs@Cu2O, coupled with strong GSH depletion, single drug injection and ultrasound (US) irradiation effectively eliminate tumors. This innovative heterojunction sonosensitizer offers a promising pathway for clinical anti-tumor treatment.</div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"665 ","pages":"Pages 681-692"},"PeriodicalIF":9.7000,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Colloid and Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021979724006775","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

The efficacy of electron-hole separation in a single sonosensitizer and the complexities of the tumor microenvironment (TME) present significant challenges to the effectiveness of sonodynamic therapy (SDT). Designing efficient sonosensitizers to enhance electron-hole separation and alleviate TME resistance is crucial yet challenging. Herein, we introduce a novel Z-scheme heterojunctions (HJs) sonosensitizer using Fe-doped carbon dots (CDs) as auxiliary semiconductors to sensitize cubic Cu₂O (Fe-CDs@Cu₂O) for the first time. Fe-CDs@Cu₂O demonstrated enhanced SDT effects due to improved electron-hole separation. Additionally, the introduction of Fe ions in CDs synergistically enhances Fenton-like reactions with Cu ions in Cu₂O, resulting in enhanced chemodynamic therapy (CDT) effects. Moreover, Fe-CDs@Cu₂O exhibited rapid glutathione (GSH) depletion, effectively mitigating TME resistance. With high rates of ¹O₂ and OH generated by Fe-CDs@Cu₂O, coupled with strong GSH depletion, single drug injection and ultrasound (US) irradiation effectively eliminate tumors. This innovative heterojunction sonosensitizer offers a promising pathway for clinical anti-tumor treatment.

Abstract Image

查看原文本刊更多论文

用于 Z 型异质结增强声化学动力学协同肿瘤治疗的肿瘤微环境响应掺杂铁的碳点敏化立方氧化铜

单一声纳增敏剂的电子-空穴分离效果和肿瘤微环境（TME）的复杂性给声动力疗法（SDT）的有效性带来了重大挑战。设计高效的声纳敏化剂来增强电子-空穴分离并减轻肿瘤微环境的抗药性至关重要，但也极具挑战性。在此，我们首次介绍了一种新型 Z 型异质结（HJs）声敏化剂，它使用掺杂铁的碳点（CDs）作为辅助半导体来敏化立方氧化铜（Fe-CDs@Cu2O）。由于改善了电子-空穴分离，Fe-CDs@Cu2O 显示出更强的 SDT 效果。此外，CD 中引入的铁离子与 Cu2O 中的铜离子协同增强了 Fenton 类反应，从而增强了化学动力疗法（CDT）效果。此外，Fe-CDs@Cu2O 还能快速消耗谷胱甘肽（GSH），有效减轻 TME 的抗药性。Fe-CDs@Cu2O产生的1O2和OH速率高，再加上强大的GSH消耗，单次药物注射和超声（US）照射就能有效消除肿瘤。这种创新的异质结声波增敏剂为临床抗肿瘤治疗提供了一条前景广阔的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Colloid and Interface Science 化学-物理化学

CiteScore

16.10

自引率

7.10%

发文量

2568

审稿时长

2 months

期刊介绍： The Journal of Colloid and Interface Science publishes original research findings on the fundamental principles of colloid and interface science, as well as innovative applications in various fields. The criteria for publication include impact, quality, novelty, and originality. Emphasis: The journal emphasizes fundamental scientific innovation within the following categories: A.Colloidal Materials and Nanomaterials B.Soft Colloidal and Self-Assembly Systems C.Adsorption, Catalysis, and Electrochemistry D.Interfacial Processes, Capillarity, and Wetting E.Biomaterials and Nanomedicine F.Energy Conversion and Storage, and Environmental Technologies

文献相关原料

公司名称

产品信息

阿拉丁

5,5′-Dithiobis-(2-nitrobenzoic acid) (DTNB)

阿拉丁

Glutathione (Reduced)

阿拉丁

EDTA-FeNa