The role of drug-coated balloons for coronary bifurcation management: results from the prospective EASTBOURNE-BIF study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-03-29 DOI:10.23736/S2724-5683.23.06443-8

Florin-Leontin Lazar, Đeiti Prvulović, Horea-Laurentiu Onea, Bernardo Cortese

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引用次数: 0

Abstract

Background: Coronary bifurcation lesions are associated with less favourable outcome as compared to other lesion subsets. The role of drug-coated balloons (DCB) for bifurcation lesions has been only investigated in small studies so far, which reported encouraging results. We here describe the results of EASTBOURNE-BIF prospective registry, in which a sirolimus-DCB was used for the treatment of bifurcation lesions.

Methods: Overall, 194 patients with bifurcations lesions identified in the EASTBOURNE study (Medina 1.1.1/1.1.0/1.0.1/0.1.1/0.1.0) were compared with 1049 patients with de-novo lesions from the same registry. Both a blended-strategy using a drug-eluting stent in the main branch and a DCB in the side branch as well as a full-DCB approach were used in the treatment of bifurcation lesions.

Results: At one year of follow-up the study primary endpoint, target-lesion revascularization occurred at a similar rate in the bifurcation group versus the de-novo group (4.2 vs. 2%, P=0.28). Similar outcomes were observed in terms of all-cause death (3.3 vs. 1.4%, P=0.138), major adverse cardiovascular events (8.8 vs. 5.2%, P=0.081) and the rate of spontaneous myocardial infarction (2.8 vs. 1.0%, P=0.117).

Conclusions: The results of EASTBOURNE-BIF study show how the use of this DCB alone or in combination with drug eluting stents could represent a safe and effective alternative to stents for the treatment of bifurcations.

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药物涂层球囊在冠状动脉分叉管理中的作用：前瞻性 EASTBOURNE-BIF 研究的结果。

背景：与其他病变亚群相比，冠状动脉分叉病变的预后较差。药物涂层球囊（DCB）在分叉病变中的作用迄今只在小规模研究中进行过调查，并取得了令人鼓舞的结果。我们在此介绍 EASTBOURNE-BIF 前瞻性登记的结果，其中使用了西罗莫司-DCB 治疗分叉病变：方法：在EASTBOURNE研究（Medina 1.1.1/1.1.0/1.0.1/0.1.1/0.1.1/0.1.0）中发现的194例分叉病变患者与来自同一登记处的1049例新发病变患者进行了比较。在治疗分叉病变时，既采用了在主支使用药物洗脱支架、在侧支使用 DCB 的混合策略，也采用了全 DCB 方法：随访一年后，研究的主要终点--目标病变血管再通发生率在分叉组与去新病变组相似（4.2% 对 2%，P=0.28）。在全因死亡（3.3 vs. 1.4%，P=0.138）、主要不良心血管事件（8.8 vs. 5.2%，P=0.081）和自发性心肌梗死率（2.8 vs. 1.0%，P=0.117）方面也观察到相似的结果：EASTBOURNE-BIF研究结果表明，单独使用这种DCB或将其与药物洗脱支架联合使用，是治疗分叉的一种安全有效的支架替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.