Neck Circumference in Polycystic Ovary Syndrome: A Systematic Review and Bootstrapped Meta-Analysis with GRADE Approach.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2024-03-28 DOI:10.1159/000538092

Mona Lisa, Seshadri Reddy Varikasuvu, Subodh Kumar, Saurabh Varshney, Pratima Gupta, Ashoo Grover, Faustino R Pérez-López, Vanita Lal, Harminder Singh, Shiv Kumar Mudgal

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引用次数: 0

Abstract

Introduction: Our aim was to perform a systematic review and meta-analysis for the association of neck circumference (NC) in polycystic ovary syndrome (PCOS) patients as compared to non-PCOS controls.

Methods: Primarily the PubMed/MEDLINE database and others such as SCOPUS, Google Scholar, Cochrane Library, were searched up to November 15, 2023 for observational studies comparing NC in PCOS versus non-PCOS women. The mean and SD values of NC and other covariates in PCOS and control groups were extracted by two independent reviewers, and the quality and risk of bias assessment was done using Newcastle-Ottawa Scale. The meta-analysis employed combined standardized mean differences (SMD) with 95% confidence intervals (CI) to compare NC between PCOS patients and controls. The heterogeneity and validity were addressed by subgroup, meta-regression, and sensitivity analyses. We conducted a Bootstrapped meta-analysis using 1,000 and 10,000 simulations to test the accuracy of the obtained results. The certainty of evidence was assessed by the GRADE approach.

Results: Our meta-analysis included 9 observational studies. The PCOS patients showed significantly higher NC values than the non-PCOS controls (SMD: 0.66, 95% CI: 0.41-0.91, p < 0.0001). In the bootstrap meta-analysis, the accuracy of the observed findings was proved (SMD = 0.66, 95% CI = 0.42-0.91) for the NC outcome. No publication bias was detected in the funnel plot analysis using Begg's and Egger's tests. The 95% prediction interval of 0.036-1.28 suggests that the true outcomes of the studies are generally in the same direction as the estimated average outcome. The sensitivity analysis provided the robustness of the outcome, and no single study was overly influential on the pooled estimate.

Conclusion: This meta-analysis provides accurate evidence for significantly higher NC values in PCOS as compared to non-PCOS controls. There is no sufficient evidence on the diagnostic accuracy measures for NC in PCOS. Hence, further research on its diagnostic utility in PCOS is needed.

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多囊卵巢综合征的颈围：采用 GRADE 方法进行的系统综述和引导荟萃分析。

简介：我们的目的是对多囊卵巢综合征（PCOS）患者的颈围（NC）与非PCOS对照组的相关性进行系统回顾和荟萃分析：主要在 PubMed/MEDLINE 数据库以及 SCOPUS、Google Scholar、Cochrane Library 等其他数据库中查找截至 2023 年 11 月 15 日的多囊卵巢综合征与非多囊卵巢综合征女性颈围比较的观察性研究。由两名独立审稿人提取多囊卵巢综合征组和对照组中NC和其他协变量的平均值和标度值，并采用纽卡斯尔-渥太华量表对研究的质量和偏倚风险进行评估。荟萃分析采用合并标准化均值差异（SMD）和 95% 置信区间（CI）来比较多囊卵巢综合征患者和对照组之间的 NC。通过亚组、元回归和敏感性分析解决了异质性和有效性问题。我们使用 1000 次和 10000 次模拟进行了 Bootstrapped 元分析，以检验所得结果的准确性。我们采用 GRADE 方法评估了证据的确定性：我们的荟萃分析包括 9 项观察性研究。多囊卵巢综合症患者的 NC 值明显高于非多囊卵巢综合症对照组（SMD 0.66，95% CI 0.41-0.91，pConclusion）：这项荟萃分析提供了准确的证据，证明多囊卵巢综合症患者的 NC 值明显高于非多囊卵巢综合症对照组。关于多囊卵巢综合征中 NC 的诊断准确性衡量标准，目前还没有足够的证据。因此，需要进一步研究其在多囊卵巢综合症中的诊断效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.