Prognosis of primary breast salivary gland-type carcinoma: a propensity score-matching analysis with invasive carcinoma of no special type based on the SEER database for years 2010–2020

IF 4 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Cancer Pub Date : 2024-03-28 DOI:10.1007/s12282-024-01564-8

Ewe Seng Ch’ng

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引用次数: 0

Abstract

Background

Primary breast salivary gland-type carcinoma has weak evidence to support its management due to its rare occurrence and limited data regarding its clinicopathological features and prognosis. Therefore, this study aimed to assess clinicopathological features and prognosis for this type of carcinoma diagnosed over the past decade and compared those to the common breast invasive carcinoma of no special type (NST).

Methods

This study used the Surveillance, Epidemiology, and End Results (SEER) database to extract data regarding primary breast salivary gland-type carcinoma. Using a propensity score-matching approach, the prognosis was compared with invasive carcinoma, NST.

Results

This study included 488 cases of salivary gland-type carcinoma and 375,660 cases of invasive carcinoma, NST, giving an occurrence ratio of 1 to 770. Adenoid cystic carcinoma (81%) formed the majority of salivary gland-type carcinoma, followed by secretory carcinoma (13%). For salivary gland-type carcinoma, acinic cell carcinoma histological type, tumor grade 3, HER2-overexpressed status, and higher AJCC stage groups were significant worse prognostic factors for breast cancer-specific survival in univariate analyses (p < 0.05). Nonetheless, tumor grade 3 and higher AJCC stage groups remained as significant independent prognostic factors in multivariate analysis (p < 0.05). The apparent better breast cancer-specific survival of salivary gland-type carcinoma as compared to that of invasive carcinoma, NST, was diminished following adjustment for differences in baseline clinicopathological features and treatment-related variables.

Conclusions

This study suggests that when managing primary breast salivary gland-type carcinoma, greater emphasis should be given to the tumor grade and AJCC stage group in addition to acinic cell carcinoma histological type and HER2 overexpression. Conventional prognostic factors are important as salivary gland-type carcinoma had similar prognosis as invasive carcinoma, NST, following adjustment for confounding variables.

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原发性乳腺唾液腺型癌的预后：基于 2010-2020 年 SEER 数据库与无特殊类型浸润性癌的倾向得分匹配分析

背景原发性乳腺唾液腺型癌由于其罕见的发生率和有限的临床病理特征及预后数据，支持其治疗的证据不足。因此，本研究旨在评估过去十年中确诊的该类型癌症的临床病理特征和预后，并将其与常见的无特殊类型乳腺浸润性癌（NST）进行比较。方法本研究使用监测、流行病学和最终结果（SEER）数据库提取原发性乳腺唾液腺型癌的相关数据。结果本研究纳入了 488 例唾液腺型癌和 375,660 例浸润性癌（NST），发生率为 1 比 770。腺样囊性癌（81%）占涎腺型癌的大多数，其次是分泌性癌（13%）。就唾液腺型癌而言，在单变量分析中，针状细胞癌组织学类型、肿瘤 3 级、HER2-表达状态和较高的 AJCC 分期组别是乳腺癌特异性生存率较差的重要预后因素（p <0.05）。然而，在多变量分析中，肿瘤分级 3 级和 AJCC 分期较高的组别仍然是重要的独立预后因素（p < 0.05）。在对基线临床病理特征和治疗相关变量的差异进行调整后，涎腺型乳腺癌比浸润性乳腺癌（NST）更佳的乳腺癌特异性生存率有所降低。结论这项研究表明，在处理原发性乳腺涎腺型癌时，除了棘细胞癌组织学类型和 HER2 过度表达外，还应更加重视肿瘤分级和 AJCC 分期组别。传统的预后因素非常重要，因为在对混杂变量进行调整后，涎腺型癌的预后与浸润性癌（NST）相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.70

自引率

2.50%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Breast Cancer, the official journal of the Japanese Breast Cancer Society, publishes articles that contribute to progress in the field, in basic or translational research and also in clinical research, seeking to develop a new focus and new perspectives for all who are concerned with breast cancer. The journal welcomes all original articles describing clinical and epidemiological studies and laboratory investigations regarding breast cancer and related diseases. The journal will consider five types of articles: editorials, review articles, original articles, case reports, and rapid communications. Although editorials and review articles will principally be solicited by the editors, they can also be submitted for peer review, as in the case of original articles. The journal provides the best of up-to-date information on breast cancer, presenting readers with high-impact, original work focusing on pivotal issues.